grant
Environmental Exposures and ADRD in the Health and Retirement Study Cohort
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Apr 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AD and related dementiaAD pathwayAD related dementiaAD-associated pathwaysAD-related pathwaysAD-specific pathwaysADRDAgeAir PollutionAlzheimer disease mechanismAlzheimer pathwayAlzheimer's Disease PathwayAlzheimer's Disease and its related dementiasAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease and related forms of dementiaAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's mechanismAlzheimer's related pathwaysAmentiaBiological MarkersBloodBlood Reticuloendothelial SystemBlood SerumCell BodyCellsChemicalsCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexComplex MixturesDNA MethylationDataDementiaDisturbance in cognitionEnvironmentEnvironmental ExposureEnvironmental FactorEnvironmental Risk FactorExposure AssessmentExposure toFamilyFutureGene TranscriptionGenetic TranscriptionHealth and Retirement StudyHistoryImmuneImmunesImpaired cognitionImpairmentIncidenceIndividualInterventionKnowledge PortalKnowledge base PortalKnowledgebase PortalLinkLipidsLiquid substanceLong-term cohortLongitudinal cohortMeasuresMediationMediatorMetalsModificationMolecularNational Institute of AgingNational Institute on AgingNegotiatingNegotiationNeighborhoodsNetwork AnalysisNeurotoxinsOutcomePFASParticipantPathway AnalysisPathway interactionsPersonsPesticidesPhenotypePlayPollutionPoly-fluoroalkyl substancesPopulationPositionPositioning AttributePredispositionPreventionPublic HealthRNA ExpressionRecommendationRecording of previous eventsResearchRisk FactorsSamplingSampling StudiesSerumSisterSocial ConditionsSocializationSocietal ConditionsSocio-economic statusSocioeconomic StatusStressSusceptibilityTestingTranscriptionUnited StatesWorkagesbio-markersbiologic markerbiomarkerchemical resourceco-exposuresco-occurring exposurecognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingcohortcohort investigationcohort researchcombined exposurecomplex exposureconcurrent exposuredementia riskenvironmental chemicalenvironmental riskexposomeexposomicsexposure analysisexposure evaluationexposure measurementexposure mixtureexposure profilingexposure surveyexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesfluidgeographic differencegeographic variationhistoriesinvestigate cohortlipidomicsliquidmechanisms in ADmechanisms in Alzheimer's diseasemetabolism measurementmetabolomicsmetabonomicsmixed exposuremolecular biomarkermolecular markerneurotoxicantnon targeted analysisnontargeted approachnontargeted methodnontargeted techniquepathwaypathways associated with ADpathways associated with Alzheimer'spathways contribute to Alzheimer'spathways involved in Alzheimer diseasepathways that contribute to ADpathways that drive ADpathways underlying Alzheimer'sperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancespollutantpolyfluorinated alkyl substancespolyfluoroalkyl substancespopulation basedpre-clinicalpreclinicalprospectiveresponserisk factor for dementiarisk for dementiasexsimultaneous exposuressocialsocio-economicsocio-economic positionsocio-economicallysocioeconomic positionsocioeconomicallysocioeconomicsstressorstudy cohortsurvey cohorttoxicantuntargeted analysisuntargeted analytical approachuntargeted analytical methoduntargeted analytical techniqueuntargeted approachuntargeted investigationsuntargeted methoduntargeted strategyuntargeted technique
Description preview
Alzheimer’s disease and related dementias (ADRD) are a growing public health burden and understanding modifiable ADRD causes is a national priority. Many classes of environmental chemicals, such as pesticides and per- and polyfluoroalkyl substances (PFASs) contain known neurotoxicants and are thus likely to contribute to ADRD risk, but we lack…
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