grant
Enhancing T and B cell responses to Plasmodium via IL-15
Organization HENNEPIN HEALTHCARE RESEARCH INSTITUTELocation MINNEAPOLIS, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY202621+ years oldAb responseAdoptive TransferAdultAdult HumanAnti-malarial drug resistanceAnti-malarial drug resistantAntibodiesAntibody FormationAntibody ProductionAntibody ResponseAreaAttenuatedB blood cellsB cellB cell differentiationB cellsB lymphocyte differentiationB-CellsB-LymphocytesB-cellBloodBlood Reticuloendothelial SystemCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCSIFCSIF-10Cell BodyCell DifferentiationCell Differentiation processCell FunctionCell Mediated ImmunologyCell PhysiologyCell ProcessCell-Mediated ImmunityCellsCellular FunctionCellular ImmunityCellular PhysiologyCellular ProcessCessation of lifeClass II GenesClinicalClinical TrialsComplexCytokine Synthesis Inhibitory FactorCytotoxic cellDataDeathDiseaseDisorderEffectivenessEffector CellExposure toFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesGenerationsGeneticGerminal CenterHLA Class II GenesHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHepatic CellsHepatic Parenchymal CellHepatocyteHistologyHumanHumoral ImmunitiesIL-10IL-15IL10IL10AIL15IL15 ProteinImmune Modulation TherapyImmune mediated therapyImmune responseImmunityImmunologically Directed TherapyImmunotherapyImpairmentInducer CellsInducer T-LymphocytesInfectionInflammationInflammatory ResponseInsecticide ResistanceInterleukin 10 PrecursorInterleukin-10Interleukin-15Interleukin-15 PrecursorK lymphocyteKO miceKnock-outKnock-out MiceKnockoutKnockout MiceKnowledgeLYT3LicensingLiverLiver CellsLocationMGC9721MHC Class IIMHC Class II GenesMaintenanceMalariaMalaria VaccinesMalarial VaccinesMediatingMemoryMemory B CellMemory B-LymphocyteMiceMice MammalsModelingModern ManMolecularMurineMusNK CellsNatural Killer CellsNull MousePaludismParasitesPathologicPathway interactionsPeptide-MHCPeptide-Major Histocompatibility Protein ComplexPeptide/MHC ComplexPersonsPhenotypePlasmodiumPlasmodium InfectionsPlasmodium bergheiPlasmodium vaccinePredispositionProcessProductionReagentRoleSporozoite vaccineSporozoitesStructure of germinal center of lymph nodeSubcellular ProcessSusceptibilityT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTestingTransmissionVaccinationVaccinesWorkacquired immunityadulthoodanti-malarial resistanceantibody biosynthesisantibody-based immunityattenuateattenuatescellular differentiationconditional knock-outconditional knockoutcytokine based immunotherapycytokine based therapycytokine immunotherapycytokine therapycytokine treatmentdesigndesigningdevelop a vaccinedevelop therapydevelop vaccinesdevelopment of a vaccineefficacy testingexperienceflow cytophotometryglobal healthhepatic body systemhepatic organ systemhost responseimmune modulating strategyimmune modulatory strategyimmune modulatory therapiesimmune modulatory treatmentimmune regulation therapyimmune regulation treatmentimmune regulatory therapyimmune response to vaccinationimmune response to vaccinesimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmune-modulation treatmentimmunization strategyimmuno therapyimmunoglobulin biosynthesisimmunomodulation therapyimmunomodulation treatmentimmunomodulator therapiesimmunomodulator treatmentimmunomodulator-based therapiesimmunomodulatory biologicsimmunomodulatory strategyimmunomodulatory therapiesimmunomodulatory treatmentimmunoregulatory therapyimmunoregulatory treatmentimmunoresponseimprovedinsecticide resistantintervention developmentmemory CD4 T cellmemory CD4 T lymphocytemouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpMHCpathwaypreventpreventingrational designresident memory T cellresistance to anti-malarial drugresistant to anti-malarial drugresponserodent plasmodiascRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial roletherapeutic immunomodulationtherapeutic immunoregulationtherapy developmentthymus derived lymphocytetissue resident memory T celltransmission processtreatment developmentvaccination strategyvaccine associated immune responsevaccine developmentvaccine efficacyvaccine for immunotherapyvaccine immune responsevaccine immunogenicityvaccine immunotherapyvaccine induced immune responsevaccine-based immunotherapyvaccines against malaria
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PROJECT SUMMARY/ABSTRACT
Malaria, which results from infection with Plasmodium parasites, is a significant global health problem
with nearly 250 million clinical cases and over 600,000 deaths annually worldwide. With growing anti-malarial
drug and insecticide resistance, new therapeutic strategies and highly effective vaccines are urgently…
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