grant
Enhancing anti-tumor immunity in head and neck neoplasms
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAbscissionActive Follow-upAdjuvantAdjuvant ChemotherapyAdjuvant Drug TherapyAdjuvant RadiotherapyAdjuvant TherapyAdultAdult HumanAlcohol abuseAmericanAnti-EGFR Monoclonal AntibodyAnti-Epidermal Growth Factor Receptor Monoclonal AntibodyAnti-VEGFAnti-VEGF Humanized Monoclonal AntibodyAnti-VEGF RhuMAbAsialiaBasic ResearchBasic ScienceBlood NeutrophilBlood Polymorphonuclear NeutrophilBone-Derived Transforming Growth FactorCDDPCarcinogen exposureCaringCase SeriesCausalityCell BodyCell TherapyCellsCessation of lifeCetuximabChildhoodChronicCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumClinicalClinical ResearchClinical StudyClinical Treatment MoabClinical TrialsCysplatynaDataDeathDeglutition DisordersDevelopmentDichlorodiammineplatinumDiseaseDisorderDistant CancerDistant MetastasisDropsDysphagiaDysphoniaEngineeringEpithelial NeoplasmsEtOH abuseEtiologyExcisionExtirpationFutureGoalsHNSCCHPVHPV + oropharyngeal carcinomaHPV 16HPV 6HPV mediated oropharynx cancerHPV oropharyngeal cancerHPV positive oropharyngeal cancerHPV positive oropharynx cancerHPV related oropharyngeal cancerHPV related oropharyngeal carcinomaHPV type 6HPV+ OPCHPV+ oropharyngeal cancerHPV-16HPV-OPCHPV-associated oropharyngeal cancerHPV-driven oropharyngeal cancerHPV-related OPCHPV-related oropharyngeal cancerHPV16HPV6Head and NeckHead and Neck NeoplasmsHead and Neck Squamous Cell CarcinomaHead and neck structureHuman Papilloma VirusHuman PapillomavirusHuman papilloma virus type 16Human papillomavirus 16Human papillomavirus 6Human papillomavirus driven oropharyngeal cancerHuman papillomavirus related oropharyngeal carcinomaHuman papillomavirus type 16Human papillomavirus type 6Human papillomavirus- related oropharyngeal cancerHuman papillomavirus-associated oropharyngeal cancerHyposalivationImmune mediated therapyImmunologically Directed TherapyImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapeutic agentImmunotherapyIncidenceIndividualInduction TherapyInfectious Human Wart VirusInstitutionKeytrudaLaryngealLarynxLarynx Head and NeckLeadLinkLong-term infectionMHC ReceptorMajor Histocompatibility Complex ReceptorMalignant Oral Cavity NeoplasmMalignant Oral Cavity TumorMalignant Oral NeoplasmMarrow NeutrophilMedicalMilk Growth FactorMoAb VEGFMonoclonal AntibodiesMonoclonal Antibody Anti-VEGFMouth CancerMouth DiseasesMouth DrynessMucosaMucosal TissueMucous MembraneNEOADJNational Institutes of HealthNatureNeoadjuvantNeoadjuvant StudyNeoadjuvant TherapyNeoadjuvant TreatmentNeutrophilic GranulocyteNeutrophilic LeukocyteNewly DiagnosedOperative ProceduresOperative Surgical ProceduresOral CancerOral Cavity DiseaseOral Cavity DisorderOral Cavity Squamous Cell CarcinomaOral DiseaseOral DisorderOral StageOral squamous cell carcinomaOropharyngealOropharynxOropharynxsOtolaryngologistPD 1PD-1PD1PapillomaPapillomatosesPathologicPathologyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPenetrancePeyrone's ChloridePeyrone's SaltPharyngeal structurePharynxPhonation DisordersPlatelet Transforming Growth FactorPlatinum DiamminodichloridePolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPreventative ImmunizationPreventative vaccinationPreventive ImmunizationPreventive vaccinationPrognosisProgression-Free SurvivalsProphylactic immunizationProphylactic vaccinationRadiationRadiation DoseRadiation Dose UnitRadiation therapyRadiotherapeuticsRadiotherapyReceptor ProteinRecombinant Humanized Anti-VEGF Monoclonal AntibodyRecombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth FactorRecurrenceRecurrentRecurrent diseaseRecurrent respiratory papillomatosisRelapseRelapsed DiseaseRemovalResearchResectableRespiratory TherapyRhuMAb VEGFRiskSCCHNSafetySalivary hypofunctionSocial isolationSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurvival RateSwallowing DisordersT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteTGF BTGF-betaTGF-βTGFbetaTGFβTaxotereThroatToxic effectToxicitiesTracheaTrachea ProperTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslatingTumor ImmunityUnited StatesUnited States National Institutes of HealthUnresectableViral AntigensXerostomiaXerostomicactive followupadjuvant radiation therapyadjuvant treatmentadulthoodairflow limitationairflow obstructionairway limitationairway obstructionalcohol co-abusealcohol problemanti-tumor immune responseanti-tumor immunityantitumor immunityaptyalismbevacizumabcancer immunitycareercausationcell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapycheck point blockadecheckpoint blockadechemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapychemotherapychronic infectioncis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumclinical centercohortdesigndesigningdevelopmentaldisease causationdisease controldisorder controldocetaxeldocetaxoldry mouthearly clinical trialearly phase clinical trialeffective therapyeffective treatmentethanol abusefinancial toxicityfollow upfollow-upfollowed upfollowuphazardous alcohol usehead and neck squamous carcinomahead and neck squamous cell cancerhead and neck tumorheavy metal Pbheavy metal leadhigh riskhuman papilloma virus 16human papillomavirus mediated oropharynx cancerhuman papillomavirus positive oropharyngeal cancerhuman papillomavirus positive oropharyngeal carcinomahuman papillomavirus positive oropharynx carcinomahuman papillomavirus+ oropharyngeal cancerimmune check point blockadeimmune checkpoint blockadeimmune drugsimmune suppressionimmune suppressive activityimmune suppressive functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic therapeuticsimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunotherapeuticsimmunotherapy agentimprovedinclusion criteriainduction therapiesmAbsmalignant mouth neoplasmmalignant mouth tumormonoclonal Absmouth SCCmouth disordermouth squamous cell carcinomaneutrophilnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnon vaccinatednot vaccinatednovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyobstructed airflowobstructed airwayoral cavity SCCoral cavity canceroral drynessoral immunotherapyoral pharyngealoral squamous canceroral squamous carcinomapatient oriented outcomespediatricpembrolizumabpersistent infectionpre-clinicalpreclinicalpreservationproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol useprogrammed cell death 1programmed cell death protein 1programmed death 1programsprospectiveradiation treatmentradio-chemo-therapyradio-chemotherapyradiochemotherapyreceptorrelapse patientsresectionrespiratoryrespiratory airway obstructionresponserhuMabVEGFrisk stratificationsalivary gland hypofunctionsle2socialstandard of carestratify risksurgerysystemic lupus erythematosus susceptibility 2therapeutic HPV vaccinationstherapeutic evaluationtherapeutic human papilloma virus vaccinationstherapeutic human papillomavirus vaccinationstherapeutic stratificationtherapeutic testingtherapeutic vaccinethymus derived lymphocytetobacco abusetreatment strategytreatment stratificationtreatment vaccinestreatment with radiationtumortype 16 Human papilloma virustype 16 Human papillomavirusunvaccinatedvaccine for the treatmentvaccine for treatmentvirus antigenvoice boxwart viruswindpipe
Description preview
Project 1: Optimize anti-tumor immunity with neoadjuvant immunotherapy for oral cavity cancers Background: Oral squamous cell carcinoma (OSCC), typically caused by carcinogen exposure, carries a poor prognosis. Roughly half of all patients with newly-diagnosed advanced stage OSCC will relapse in two years despite receiving maximal treatment…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click