grant
Enhanced Delivery of Cytotoxic Neural Stem Cells for Treatment of Glioblastoma Multiforme Using an Innovative In-situ Thermogelling Hydrogel and Focused Ultrasound
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 13 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025APO2LAbscissionAddressApo-2LBBB permeabilizationBBB permeableBiocompatible MaterialsBiodistributionBiomaterialsBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain CancerBrain Nervous SystemCell BodyCellsCharacteristicsChitosanClinicalCombined Modality TherapyDetectable Residual DiseaseDevelopmentDiagnosisDimensionsDiseaseDisorderDistantDoseDrug DeliveryDrug Delivery SystemsEncephalonEngineeringEnhancement TechnologyEvaluationExcisionExtirpationExtravasationFocused UltrasoundFocused Ultrasound AblationFocused Ultrasound TherapyFocused Ultrasound TreatmentFormulationFosteringGlioblastomaGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHealth BenefitHemato-Encephalic BarrierHigh Power Focused UltrasoundHigh-intensity focused ultrasoundHomeHomingHydrogelsImprove AccessIn SituInjectableInjectionsIntrasurgical Resection CavityInvestigatorsK CellsKiller CellsLeakageMalignant CellMalignant Tumor of the BrainMalignant neoplasm of brainMarketingMediatingMethodsMicrobubblesMinimal Residual DiseaseModalityMultimodal TherapyMultimodal TreatmentNatureNeural Stem CellOperative ProceduresOperative Surgical ProceduresOtomyPatientsPoliglusamPre-Clinical ModelPreclinical ModelsProcessPropertyProteinsPublic HealthRecurrenceRecurrentRecurrent NeoplasmRecurrent tumorRegimenRemovalResearch PersonnelResearchersResection CavityResidualResidual NeoplasmResidual TumorsResidual stateResolutionRouteSafetySpillageSurgicalSurgical InterventionsSurgical ProcedureSurgical RemovalSurgical incisionsSurgically-Created Cystic Resection CavitySurgically-Created Resection CavityTL2TNFSF10TNFSF10 geneTRAILTechnologyTestingTherapeuticTimeToxic effectToxicitiesTreatment ProtocolsTreatment RegimenTreatment ScheduleTreatment outcomeTumor CellVariantVariationallergen responseallergic responseallergy responseanti-cancerbiological materialbiomaterial scaffoldbioscaffoldblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablecancer cellcell engineeringcellular engineeringchemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapyclinical developmentcombination therapycombinatorialcombined modality treatmentcombined treatmentcytotoxicdelivery vectordelivery vehicledensitydesigndesigningdetermine efficacydevelopmentalefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy outcomesevaluate efficacyexamine efficacyglioblastoma multiformehomeshydrogel scaffoldimprovedin vivoincisioninduced neural progenitorinduced neural stem cellinduced neural stem cellsinduced neuronal progenitorinduced neuronal stem cellinduced neuronal stem cellsinduced neuroprogenitorinnovateinnovationinnovativemanufacturing processmigrationminimally invasivemouse modelmulti-modal therapymulti-modal treatmentmurine modelneoplasm recurrenceneoplastic cellnerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneuro-oncologyneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneurooncologyneuroprogenitornew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpre-clinicalpreclinicalprogenitor and neural stem cellsprogenitor cell based therapyprogenitor cell therapyprogenitor cell treatmentprogenitor therapyprogenitor treatmentradio-chemo-therapyradio-chemotherapyradiochemotherapyrational designresectionresidual diseaseresolutionsresponsescaffoldscaffoldingself-renewself-renewalspatial and temporalspatial temporalspatiotemporalspongioblastoma multiformestem and progenitor cell therapystem cell based therapystem cell mediated therapystem cell therapeuticsstem cell therapystem cell treatmentstem cell-based therapeuticstem cell-based treatmentsurgerysurvival outcometherapy optimizationtreatment optimizationtumor
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PROJECT SUMMARY
Glioblastoma multiforme (GBM) is the most aggressive form of brain cancer and ~90% of GBM patients die
within 24 months after diagnosis.1 Treatment options for GBM include surgery and chemoradiation however,
recurrence is common, and the disease is universally fatal.2,3 Over the past 20 years, induced neural stem cells
(iNSCs) have…
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