grant

Engineering Tissue Level Targeting of Biologic Drugs via Automated Interfacial Microneedle Pumps

Organization GEORGIA INSTITUTE OF TECHNOLOGYLocation ATLANTA, UNITED STATESPosted 1 Aug 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AreaBiologicalBlood VesselsBody TissuesCancersCardiac DiseasesCardiac DisordersCardiac NeoplasmsCardiac TumorCardiac infarctionCaringCharacteristicsCirculationComputer ModelsComputerized ModelsDiabetes MellitusDiffuseDiffusionDiseaseDisorderDrug ImplantsDrugsGenerationsHealth Care ProfessionalHealth Care SystemsHealth ProfessionalHeartHeart DiseasesHeart NeoplasmsHeart TumorImmune mediated therapyImmunologically Directed TherapyImmunotherapyInjectionsLengthMalignant CellMalignant NeoplasmsMalignant TumorManualsMechanicsMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorModelingMucosaMucosal TissueMucous MembraneMuscleMuscle TissueMyocardialMyocardial InfarctMyocardial InfarctionNeedlesNeoplasm MetastasisOral AdministrationOral Drug AdministrationPenetrationPharmaceutical PreparationsPhysiologicPhysiologicalPropertyPumpResearchSecondary NeoplasmSecondary TumorSolid NeoplasmSolid TumorStandardizationSubcutaneous InjectionsSystemTherapeutic EffectTherapeutic ImplantTissue EngineeringTissuesTreatment EfficacyTumor TissueWound Repairbioengineered tissuebiologiccancer cellcancer metastasiscardiac infarctclinical translationclinically translatablecomputational modelingcomputational modelscomputer based modelscomputerized modelingcoronary attackcoronary infarctcoronary infarctioncytokinediabetesdiffuseddiffusesdiffusingdiffusionsdrug distributiondrug/agentengineered tissuefluid flowgastrointestinalheart attackheart disorderheart infarctheart infarctionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyinterfacialintervention efficacyintraoral drug deliverymacromoleculemalignancymechanicmechanicalmetermuscularneoplasm/cancerpressurepreventpreventingside effectsubdermal injectionsuccesstherapeutic efficacytherapy efficacytooltumor cell metastasisuptakevascularwound healingwound recoverywound resolution
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Project Summary/Abstract:
Biologic drugs have transformed the treatments of a variety of diseases, including diabetes, cancer, and heart
disease. However, their large size prevents them from easily diffusing into targeted tissues when administered
orally or via subcutaneous injection. For example, gastrointestinal mucosal tissue, myocardial muscle…

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Engineering Tissue Level Targeting of Biologic Drugs via Automated Interfacial Microneedle Pumps — GEORGIA INSTITUTE OF | Dev Procure