grant
Engineering Heterocellular Human Skeletal Muscle Tissues to Recreate and Study Native Stem Cell Niche Function
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAdultAdult HumanAgingAutoimmune DiseasesAutoregulationBiochemicalBiological MimeticsBiomimeticsBiophysicsBlood VesselsBlood capillariesBody TissuesCancersCell BodyCell CommunicationCell Communication and SignalingCell CountCell Culture TechniquesCell DifferentiationCell Differentiation processCell FunctionCell InteractionCell NumberCell PhysiologyCell ProcessCell SignalingCell secretionCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCellular SecretionChronic DiseaseChronic IllnessCo-cultureCocultivationCocultureCoculture TechniquesComplexCongenital DisordersConnective Tissue CellsConnective and Soft Tissue CellDenervationDevelopmentDiseaseDisorderDrugsDysfunctionECMEmbryonic Muscle CellsEndothelial CellsEngineeringExerciseExtracellular MatrixExtracellular Signal-Regulated Kinase GeneFiberFunctional disorderGeneralized GrowthGrowthHeterogeneityHomeostasisHumanHypoxiaHypoxicImmuneImmunesImpairmentIn VitroInflammationInjuryIntermediary MetabolismIntracellular Communication and SignalingLacerationLeadLifeLigandsLocationLocomotionMAP Kinase GeneMAPKMaintenanceMalignant NeoplasmsMalignant TumorMedicationMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMitogen-Activated Protein Kinase GeneModelingModern ManMotor CellMotor NeuronsMuscleMuscle AtrophyMuscle CellsMuscle DiseaseMuscle DisordersMuscle FibersMuscle TissueMuscle satellite cellMuscular AtrophyMuscular DiseasesMuscular DystrophiesMyoblastsMyocytesMyodystrophicaMyodystrophyMyoneural JunctionMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyMyotubesNatural regenerationNatureNerve CellsNerve UnitNeural CellNeurocyteNeuromuscular DiseasesNeuromuscular JunctionNeuronsOrganOrganoidsOutcomeOxygen DeficiencyPatternPb elementPharmaceutical PreparationsPhenotypePhysiological HomeostasisPhysiopathologyPositionPositioning AttributePosturePrecursor Muscle CellsProgenitor CellsProliferatingRegenerationRegenerative capacityRegenerative responseRespirationRhabdomyocyteRoleSignal TransductionSignal Transduction SystemsSignalingSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSpecific qualifier valueSpecifiedStructureSubcellular ProcessSystemTherapeutic StudiesTherapy ResearchThesaurismosisTissue GrowthTissuesToxinVEGFAVEGFA geneVascular Endothelial Growth Factor AVascularizationVasculotropinVoluntary MuscleWNT Signaling PathwayWNT signalingadulthoodangiogenesisautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescapillarycell culturecell culturescell typecellular differentiationchronic disordercongenital muscle diseasecongenital muscle disorderdevelopmentaldrug/agentheavy metal Pbheavy metal leadhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsimprovedin vitro Modelin vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinjuriesinjury and repairinjury responseinnervationmalignancymetabolism disordermotoneuronmouse modelmurine modelmuscle breakdownmuscle degradationmuscle deteriorationmuscle dystrophymuscle engineeringmuscle fiber repairmuscle lossmuscle physiologymuscle progenitormuscle progenitor cellmuscle regenerationmuscle repairmuscle stem cellmuscle systemmuscle tissue repairmuscle wastingmuscularmuscular disordermuscular repairmuscular systemmyoneural disorderneoplasm/cancernerve supplyneuro-vascularneuromuscularneuromuscular degenerative disorderneuromuscular disorderneuronalneurovascularnotchnotch proteinnotch receptorsnovelontogenyparacrinepathophysiologyprogenitor cell nicheprogenitor nicherecruitregenerateregeneration abilityregeneration capacityregeneration responserepairrepairedrespiratory mechanismresponseresponse to injurysatellite cellself-renewself-renewalshear stressskeletal muscle growthsocial rolestem and progenitor cell nichestem cell nichestem cellsthree dimensionalvascularvolumetric muscle loss
Description preview
Healthy skeletal muscle is capable of multiple cycles of regeneration in response to small tears that occur during
daily activity and exercise. Central to this regenerative capacity are the muscle stem cells termed satellite cells
(SCs), which reside in specialized tissue “niches” and in response to injury activate, proliferate, and fuse to form…
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