grant
Engineering durable immunity by optimizing HIV vaccine parameters to drive long-lived plasma cell development
Organization SCRIPPS RESEARCH INSTITUTE, THELocation LA JOLLA, UNITED STATESPosted 21 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AIDSAIDS VirusAIDS/HIVAb responseAccelerationAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAdjuvantAffectAffinityAgreementAnti-Retroviral AgentsAntibodiesAntibody FormationAntibody ProductionAntibody ResponseAntigensB blood cellsB cellB cell repertoireB cellsB-CellsB-LymphocytesB-cellBlood Plasma CellBolusBolus InfusionBone MarrowBone Marrow Reticuloendothelial SystemCell LineageClinicalCommunicable DiseasesCompensationControlled EnvironmentDataDevelopmentDiseaseDisorderDoseDrugsEngineeringFlu vaccinationFutureGeneticGerminal CenterHIVHIV InfectionsHIV vaccineHIV/AIDSHIV/AIDS VaccinesHTLV-III InfectionsHTLV-III-LAV InfectionsHalf-LifeHealth PrioritiesHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHumoral ImmunitiesImmune responseImmune systemImmunityImmunizationInfectionInfectious DiseasesInfectious DisorderInfluenza immunizationInfluenza vaccinationInjectionsLAV-HTLV-IIILengthLifeLinkLiposomalLiposomesLymphadenopathy-Associated VirusMeasles VaccineMeasles virus vaccineMeasuresMediatingMedicationMemory B CellMemory B-LymphocyteMessenger RNAMethodsPersonsPharmaceutical PreparationsPlasma CellsPlasmacytesPlayPopulationPreventionProductionPropertyProphylactic treatmentProphylactic vaccination against influenzaProphylaxisProteinsRNA vaccineRNA-based vaccineReactionRegimenResearchResistanceRoleScheduleSpottingsStructureStructure of germinal center of lymph nodeTherapeutic InterventionTimeVaccinationVaccination acquired immunityVaccination induced immunityVaccinesVariantVariationViralVirus-HIVaccess to vaccinationaccess to vaccinesanti-retroviralantibody biosynthesisantibody-based immunityartificial environmentclinical relevanceclinically relevantdeliver mRNAdeliver messenger RNAdelivery system for mRNAdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldrug/agentflu immunisationglobal healthhost responsehuman immunodeficiency virus vaccineimmune system responseimmunization against measlesimmunogenimmunoglobulin biosynthesisimmunoresponseinfluenza virus vaccinationinnovateinnovationinnovativeintervention therapylife spanlifespanlipid based nanoparticlelipid nanoparticlemRNAmRNA deliverymRNA vaccinemRNA-based vaccinemessenger RNA deliverynano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodypandemicpandemic diseaseplasma cell developmentplasmocyteprimary end pointprimary endpointresistantresponseseasonal fluseasonal influenzasocial rolevaccination accessvaccination against influenzavaccination availabilityvaccination studyvaccination trialvaccine accessvaccine acquired immunityvaccine against measlesvaccine associated immunityvaccine availabilityvaccine developmentvaccine formulationvaccine platformvaccine studyvaccine trialvaccine-induced immunityvaccine-induced protection
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PROJECT SUMMARY
The HIV pandemic has been raging for nearly forty years, and despite immense effort we have yet to discover a
vaccine that can induce durable, protective immunity. HIV remains an urgent global health crisis, with 38 million
people living with HIV and 1.5 million people newly infected each year. For most infectious diseases but…
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