grant
Engineering dendritic cells to target islet antigen to pro-tolerogenic subsets for prevention and treatment of Type 1 Diabetes
Organization DANA-FARBER CANCER INSTLocation BOSTON, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2027
NIHUS FederalResearch GrantFY2026Antigen PresentationAntigen TargetingAntigen-Presenting CellsAntigensApoptosisApoptosis PathwayAutoantigensAutoimmune DiseasesAutoimmune StatusAutoimmunityAutologous AntigensAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBeta CellBody TissuesBrittle Diabetes MellitusCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell Communication and SignalingCell SignalingCell-Mediated Lympholytic CellsCellsClinicCytolytic T-CellCytotoxic T CellCytotoxic T-LymphocytesDataDendritic CellsDevelopmentDiabetic mouseDiseaseDisorderEngineeringEnsureFaceFunctional RNAGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic TranscriptionGoalsIDDMImmuneImmune ToleranceImmune responseImmune systemImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic ToleranceImmunologicalImmunologicallyImmunologicsInbred NOD MiceInflammationInflammatoryInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusIntracellular Communication and SignalingInvestigationJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeLentiviral VectorLentivirus VectorMessenger RNAMicroRNAsMissionNOD MouseNational Institutes of HealthNon-Obese Diabetic MiceNon-Polyadenylated RNANoncoding RNANonobese Diabetic MouseNontranslated RNAOutcomePhenotypePlayPre-Clinical ModelPreclinical ModelsPreventionPrincipal InvestigatorProcessProgrammed Cell DeathProteinsPublic HealthRNARNA ExpressionRNA Gene ProductsRecombinant DNA TechnologyRegulatory T-LymphocyteReportingResearchRibonucleic AcidRoleSelf-AntigensShapesSignal TransductionSignal Transduction SystemsSignalingSiteStimulusSudden-Onset Diabetes MellitusSurvey InstrumentSurveysT-Cell ActivationT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMT8 CellsT8 LymphocytesTestingTimeTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTransgenesTranslatingTranslationsTreatment EfficacyTregType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusUnited States National Institutes of HealthUntranslated RNAUpregulationVeiled CellsViral DiseasesVirus DiseasesWorkWritingaccessory cellactivate T cellsanergyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive T cellbiological signal transductioncell typedevelopmentaldiabetes mouse modeldrivingexhaustionexpectationfacesfacialgenetically engineeredhost responseimmune system responseimmune system toleranceimmune unresponsivenessimmunogenimmunogenicimmunological paralysisimmunoresponseinnovateinnovationinnovativeinsulin dependent diabetesinsulin dependent type 1intervention efficacyisletjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskiller T cellmRNAmiRNAmouse modelmurine modelnon-obese diabetic (NOD) micenoncodingnonobese diabetic (NOD) micenovelpre-clinical studypreclinical studypreventpreventingpromoterpromotorregulatory T-cellsresponseself-reactive T cellsocial roletherapeutic candidatetherapeutic efficacytherapy efficacythymus derived lymphocytetranscription factortransgenetranslationtype I diabetestype one diabetesviral infectionvirus infectionvirus-induced diseaseβ-cellβ-cellsβCell
Description preview
Project Summary
Although induction of antigen-specific tolerance by means of targeting such antigens to dendritic cells (DCs) has
been reported in multiple pre-clinical studies, there are currently no effective approaches using DCs in the clinic
to prevent or reverse autoimmunity. DCs have been proven to intrinsically possess the ability to…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click