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Engineering a human neuroimmune specific viral vector from Zika virus
Organization ARIZONA STATE UNIVERSITY-TEMPE CAMPUSLocation SCOTTSDALE, UNITED STATESPosted 7 Jul 2023Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAddressAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAstrocytesAstrocytusAstrogliaAutophagocytosisBiomedical EngineeringBlood - brain barrier anatomyBlood-Brain BarrierBrainBrain Nervous SystemCell BodyCell Culture SystemCell Culture TechniquesCell LineCellLineCellsClinical TrialsDNA TherapyDegenerative DisorderDegenerative Neurologic DisordersDirected Molecular EvolutionDiseaseDisorderDrugsELISAEncephalonEngineeringEnzyme-Linked Immunosorbent AssayEvolutionGene Therapy VectorsGene Transduction AgentGene Transduction VectorsGene Transfer ClinicalGenesGenetic InterventionGenome StabilityGenomic StabilityHarvestHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHemato-Encephalic BarrierHortega cellHumanHuman BiologyImmuneImmunesImmunoglobulin Enhancer-Binding ProteinImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInducer CellsInducer T-LymphocytesInfectionInflammationInflammatoryInflammatory ResponseInnate Immune ResponseMediatingMedicalMedicationMedicineMental DepressionMethodsMicrogliaModelingModern ManNF-kBNF-kappa BNF-kappaBNFKBNatural regenerationNatureNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeuroimmuneNeurologic Degenerative ConditionsNeuronal DifferentiationNeuronsNon-Polyadenylated RNANuclear Factor kappa BNuclear Transcription Factor NF-kBParalysis AgitansParkinsonParkinson DiseasePathogenicityPathologicPathologyPathway interactionsPharmaceutical PreparationsPrimary ParkinsonismPrimary Senile Degenerative DementiaPropertyRNARNA Gene ProductsRNA SeqRNA StabilityRNA sequencingRNAseqRecombinantsRegenerationResearchResistanceRibonucleic AcidSTAT1STAT1 geneSTAT91SamplingShapesSignal PathwaySourceStrains Cell LinesStructural GenesTechnologyTherapeuticTitrationsTranscription Factor NF-kBTransduction GeneTropismVAC-TXVaccine TherapyVector Mediated Transfer GenesViralViral GenomeViral VectorVirusWorkZIKAZIKVZika Virusassembloidsastrocytic gliaautophagybio-engineeredbio-engineersbioengineeringbiological engineeringbloodbrain barriercell culturecell culturescell typeclinical developmentclinical relevanceclinically relevantcultured cell linedegenerative conditiondegenerative diseasedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdepressiondirected evolutiondrug/agententire genomeenzyme linked immunoassayfull genomegene repair therapygene therapygene-based therapygenetic therapygenomic therapygitter cellhESChiPSChuman ES cellhuman ESChuman embryonic stem cellhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseinduced human pluripotent stem cellsinflammation markerinflammatory markerkappa B Enhancer Binding Proteinmesogliamicroglial cellmicrogliocytemodel of animalmutantneural inflammationneurodegenerative illnessneuroinflammationneuroinflammatoryneuronalneuropsychiatric diseaseneuropsychiatric disordernew approachesnovel approachesnovel strategiesnovel strategynuclear factor kappa betaparticlepathwayperivascular glial cellpleiotropic effectpleiotropismpleiotropypre-clinical developmentpre-clinical therapypreclinical developmentpreclinical therapypressureprimary degenerative dementiaprogramsregenerateresistantscRNA sequencingscRNA-seqsenile dementia of the Alzheimer typesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall moleculestructural genesuicide genesynthetic biologytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic vaccinationtooltranscriptome sequencingtranscriptomic sequencingtranscriptomicsvectorvirus genomevirus tropismwhole genomezikav
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PROJECT SUMMARY
Inflammation has been implicated in nearly every neuropsychiatric and degenerative disease,
yet neuroimmune cells remain nearly intractable by every available therapeutic strategy. Small
molecule drugs consistently fail clinical trials, as neuroimmune signaling pathways have essential
pleiotropic functions in neighboring cell…
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