grant
Engineered cells as agents of arthritis therapy governed by artificial signaling
Organization VANDERBILT UNIVERSITYLocation Nashville, UNITED STATESPosted 17 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AntibodiesArthritisAttenuatedAutoregulationBehaviorBiologicalBiological Response Modifier TherapyBiological TherapyBioluminescenceBiomedical EngineeringBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCartilageCartilage MatrixCartilaginous TissueCas nuclease technologyCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell TherapyCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessChondrocytesChronicClinicalClinical Treatment MoabClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollagenCollagen FiberCollagen Type IICustomDNA TherapyDNA deliveryDataDegenerative ArthritisDegenerative DisorderDegenerative polyarthritisDeteriorationDiagnosticDiseaseDisorderDrugsEngineered GeneEngineeringEnvironmentEnzyme GeneEnzymesExhibitsExtremitiesFibroblastsGene DeliveryGene ExpressionGene Transfer ClinicalGenesGenetic InterventionGoalsHealthHomeostasisHumanImmune infiltratesIn SituInflammationInflammatoryIntracellular Communication and SignalingInvestigationJoint DiseasesJointsKneeLesionLicensingLigandsLimb structureLimbsLuciferase ImmunologicLuciferasesMeasuresMechanicsMediatingMedicationMembrana Synovialis Capsulae ArticularisMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMiceMice MammalsModelingModern ManMonoclonal AntibodiesMurineMusMusculoskeletalNon-TrunkOperative ProceduresOperative Surgical ProceduresOsteoarthritisOsteoarthrosisOutcomePathologyPatientsPerformancePharmaceutical PreparationsPhenotypePhysiological HomeostasisPorosityProceduresReceptor ProteinRegenerative MedicineRegenerative engineeringRegulationResolutionSi elementSignal InductionSignal TransductionSignal Transduction SystemsSignalingSiliconSiteSleeping BeautySubcellular ProcessSurgicalSurgical InterventionsSurgical ProcedureSynovial CellSynovial MembraneSynoviumSystemT-CellsT-LymphocyteT4 CellsT4 LymphocytesTechnologyTestingTherapeuticTimeTissuesTransgenesTransplantationTransposaseTraumatic ArthritisTraumatic ArthropathyWorkarthriticarthritis therapyarthropathicarthropathiesarthropathyarticular cartilageattenuateattenuatesbio-engineeredbio-engineersbioengineeringbiologicbiological engineeringbiological signal transductionbiological therapeuticbiological treatmentbiologically based therapeuticsbiotherapeuticsbiotherapycartilage degenerationcartilage degradationcartilage regenerationcartilage repaircell based interventioncell behaviorcell engineeringcell mediated interventioncell mediated therapiescell typecell-based therapeuticcell-based therapycellular behaviorcellular engineeringcellular therapeuticcellular therapyclinical translationclinically translatablecombatcustomscytokinedegenerative conditiondegenerative diseasedegenerative joint diseasedeliver DNAdelivery vectordelivery vehicledesigndesigningdrug productiondrug/agentfeature selectiongene productgene repair therapygene therapygene-based therapygenetic therapygenomic therapyhypertrophic arthritisimmune cell infiltratein vitro Modelin vivoin vivo Modelinflamed jointinnovateinnovationinnovativejoint damagejoint degenerationjoint degradationjoint destructionjoint disorderjoint functionjoint inflammationjoint injuryjoint swellingjoint tissue degenerationjoint traumalocal drug deliverymAbsmechanicmechanicalmechanical loadmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmonoclonal Absnano particlenano-sized particlenanoparticlenanosized particlenotchnotch proteinnotch receptorsplasmid DNApost-traumatic osteoarthritisprogramsreceptorregeneration functionregenerativeregenerative functionregenerative functionalityresolutionsresponsesurgerysynthetic biologytheranosticstherapeutic transgenethymus derived lymphocytetooltransgenetransgene expressiontransplantyears lost due to disabilityyears lost to disabilityyears of life lost to disabilityyears of life lost to disease
Description preview
Project Summary
Osteoarthritis (OA), a leading cause of years lost to disability worldwide, is characterized by the breakdown of
the collagen II-rich matrix of articular cartilage, infiltration of immune cells, and inflammation of joint tissues such
as the synovium. Because no disease-modifying drugs exist to treat arthritis, surgery is the…
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