grant
Engineered biomimetic collective cancer invasion models for screening chemotherapeutic agents
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 13 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAHRRActive OxygenAnisotropyAnti-Cancer AgentsAnti-Cancer Drug ScreensAnticancer Drug Sensitivity TestsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsAntitumor Drug Screening AssaysAntitumor Drug ScreensAromatic Compound-Inducible Cytochrome P-450AssayAttenuatedBioassayBiological AssayBiological MimeticsBiomimeticsBreast CancerBreast Cancer CellBreast Cancer cell lineBreast NeoplasmsBreast PDX modelsBreast TumorsBreast tumor cell lineCP11CP12CY11CYP 1A2CYP1A1CYP1A1 geneCYP1A2CYP1A2 geneCYP1B1CYP1B1 geneCaffeine DemethylaseCancer CauseCancer ClusterCancer DrugCancer Drug TestsCancer EtiologyCancer PatientCancersCell BodyCell Culture TechniquesCell Growth in NumberCell LocomotionCell MigrationCell MovementCell MultiplicationCell ProliferationCell-Extracellular MatrixCellsCellular ExpansionCellular GrowthCellular MigrationCellular MorphologyCellular MotilityCellular ProliferationChemoresistanceClinicalCollagenCollagen FiberCollagen FibrilCytochrome P-450Cytochrome P-450 CYP1A2Cytochrome P-450 Enzyme SystemCytochrome P-450 LM4Cytochrome P-450dCytochrome P450Cytochrome P450 1A2Cytochrome P450 Family GeneDNA Molecular BiologyDevelopmentDimensionsDioxin-Inducible P3-450Drug usageDrugsECMEDS-4-hydroxylaseElectrical ImpedanceElectrodesEngineeringExposure toExtracellular MatrixFamilyFiberGeneralized GrowthGenesGenomicsGoalsGrowthHumanHydrogelsImageImage AnalysesImage AnalysisImpedanceInvadedIonsMachine LearningMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant TumorMammary CancerMammary NeoplasmsMedicationMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMicroscopyModelingModern ManMolecularMolecular BiologyMorphologyMotilityNeoplasm MetastasisNeoplastic Disease Chemotherapeutic AgentsOncologyOncology CancerOrganoidsOxygen RadicalsP(3)450P1-450P3-450P450P450 4P450 Form 4P450 orm 4P450-CP450-P3P450DXP450D\XPDX modelPatient derived xenograftPatient-derived xenograft models of breast cancerPatternPenetrationPermeabilityPharmaceutical PreparationsPharmacologyPhenacetin O-DealkylasePhenotypePlayPopulationPreclinical TestingPro-OxidantsPrognosisProliferatingProteinsRNA SeqRNA sequencingRNAseqRadialRadiusReactive Oxygen SpeciesResistanceRoleSecondary NeoplasmSecondary TumorSideSubgroupTherapeuticTimeTissue EngineeringTissue GrowthTumor CellTumor Cell InvasionTumor InvasionTumor-Specific Drug Screening TestsTumor-Specific Treatment AgentsUpregulationanti-cancer drugattenuateattenuatesbioengineered tissuebreast cancer PDXbreast cancer patient-derived xenograftbreast tumor cellcancer cellcancer invasivenesscancer metastasiscell culturecell culturescell growthcell imagingcell morphologycell motilitycellular imagingchemoresistantchemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschemotherapychemotherapy resistancechemotherapy resistantclinical relevanceclinically relevantcytochrome P450 CYP1B1cytochrome P4501B1develop therapydevelopmentaldifferential expressiondifferentially expresseddrug candidatedrug detectiondrug developmentdrug testingdrug usedrug/agentelectric impedanceengineered tissueestradiol 17-sulfate 4-hydroxylaseestradiol-4-hydroxylaseestrogen 4-hydroxylaseimage evaluationimage interpretationimagingin vivoinhibitorinhibitor druginhibitor therapeuticinhibitor therapyintervention developmentlive cell microscopymachine based learningmachine learning based pipelinemachine learning pipelinemalignancymalignant breast tumormammary tumormigrationmimeticsmortalitynano patternnanopatternneoplasm/cancerneoplastic cellontogenypatient derived xenograft modelpharmacologicpre-clinicalpre-clinical testingpreclinicalprotein expressionresistance to therapyresistantresistant to therapyresponsescreeningscreeningsshRNAshort hairpin RNAsmall hairpin RNAsocial roletherapeutic resistancetherapy developmenttherapy resistantthree dimensionalthree-dimensional modelingtranscriptional differencestranscriptome sequencingtranscriptomic sequencingtreatment developmenttreatment resistancetumortumor cell metastasis
Description preview
PROJECT SUMMARY
Metastasis is the primary cause of cancer mortality, yet few breast cancer drugs effectively inhibit metastasis.
Breast cancer cells use collective migration to remodel and align surrounding extracellular matrix (ECM) fibrils,
which facilitates invasion. Aligned tumor stroma topography can induce cluster budding and dissemination…
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