grant
Endothelin signaling in neural stem cell homeostasis and remyelination
Organization UNIVERSITY OF NOTRE DAMELocation NOTRE DAME, UNITED STATESPosted 6 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY202521+ years oldAddressAdultAdult HumanAutopsyAutoregulationAxonBiscyclohexanone OxaldihydrazoneBlood VesselsBrainBrain Nervous SystemCell Communication and SignalingCell CycleCell Division CycleCell LineCell SignalingCell secretionCellLineCellular SecretionCulturing, in vitro Vertebrate, PrimaryCuprizoneDataDegenerative Neurologic DisordersDemyelinating DiseasesDemyelinating DisordersDemyelinationsDentate FasciaDevelopmentDiseaseDisorderDisseminated SclerosisEDN1ET-1EncephalonEndothelial CellsEndothelinEndothelin A ReceptorEndothelin Type 1Endothelin-1Endothelin-1 ReceptorEndothelium-Derived Vasoconstrictor FactorsFascia DentataFoundationsFutureGliaGlial CellsGoalsGyrus DentatusGyrus HippocampiGyrus ParahippocampalisHippocampal GyrusHomeostasisHumanIn VitroInjuryIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeKolliker's reticulumMS patientMaintenanceMediatingMiceMice MammalsModelingModern ManMultiple SclerosisMurineMusMyelinMyelin SheathNatural regenerationNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNervous System InjuriesNervous System TraumaNervous System damageNeural CellNeural Degenerative DiseasesNeural InhibitionNeural Stem CellNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeurological DamageNeurological InjuryNeurological traumaNeuron DegenerationNeuronal DifferentiationNeuronsNon-neuronal cellNonneuronal cellNull MouseOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellParahippocampal GyrusPathologicPathologyPathway interactionsPeptidesPersonsPhysiological HomeostasisPlayPrimary Cell CulturesPublishingRadialRadiusRecovery of FunctionRegenerationResting progenitorRoleShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSourceStrains Cell LinesTestingToxic effectToxicitiesUnited StatesWorkadult progenitoradult stem celladulthoodantagonismantagonistbiological signal transductionbrain tissuecell behaviorcellular behaviorconditional knock-outconditional knockoutcultured cell linede-myelinating diseasesde-myelinating disordersdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdemyelinatedemyelinating conditionsdemyelination diseasesdemyelination disordersdentate gyrusdesigndesigningdetermine efficacydevelopmentaldormant stem cellefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyfunctional recoverygliogenesisimprovedinactive stem cellinjuriesinsightinsular sclerosislatent progenitorlatent stem celllateral ventriclemouse modelmultiple sclerosis patientmurine modelmyelinationnecropsynerve cementnerve stem cellneural degenerationneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneuro-vascularneuro-vascular unitneurodegenerationneurodegenerativeneurodegenerative illnessneurogenesisneurogenic progenitorsneurogenic stem cellneurological degenerationneuron progenitorsneuronalneuronal degenerationneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorneurotraumaneurovascularneurovascular unitnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypatients with MSpatients with multiple sclerosispeople with Multiple sclerosispostmortempreventpreventingprogenitor and neural stem cellsprogenitor cell differentiationprogenitor cell homeostasisprogenitor cell maintenanceprogenitor cell nicheprogenitor differentiationprogenitor maintenanceprogenitor nichepublic health relevancequiescent progenitorquiescent stem cellsre-myelinatere-myelinationregenerateremyelinateremyelinationrepairrepairedresponseresting stem cellsocial rolesomatic progenitorsomatic stem cellstem and progenitor cell nichestem and progenitor differentiationstem cell differentiationstem cell homeostasisstem cell maintenancestem cell nichestem cell quiescencesubventricular zonevascularvascular constrictionvasoconstriction
Description preview
PROJECT ABSTRACT
Endogenous neural stem cells play a crucial role in neurogenesis and gliogenesis in the adult healthy brain and
following injury or disease. In response to demyelination, or the loss of myelin sheaths surrounding axons,
endogenous neural stem cells contribute to repair by upregulating gliogenesis and differentiating into…
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