grant
Endothelial mechanisms of multiorgan dysfunction
Organization ALBANY MEDICAL COLLEGELocation ALBANY, UNITED STATESPosted 15 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AcuteAutomobile DrivingB-Cell Differentiation Factor GeneB-Cell Stimulatory Factor 2 GeneBSF-2 GeneBSF2 GeneBeta-2 Gene InterferonBioinformaticsBlood Coagulation DisordersCardiovascular PhysiologyCell Communication and SignalingCell SignalingCellular Immune FunctionCessation of lifeChronicCirculatory CollapseClinicalCoagulation DisorderCoagulopathyCritical IllnessCritically IllCytokine Signal TransductionCytokine SignalingDeathDevelopmentDiagnosisDropsyDysfunctionEdemaEndothelial CellsEndotheliumEnsureExpression SignatureFunctional disorderGene Expression ProfileGene TranscriptionGenetic TranscriptionHSF GeneHepatocyte Stimulatory Factor GeneHumanHybridoma Growth Factor GeneHydropsIFNB2 GeneIL-6 GeneIL6IL6 geneImmune responseImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImpairmentInflammationInflammatoryIntensive CareIntensive Care UnitsInterleukin 6 (Interferon, Beta 2) GeneInterleukin-6 GeneIntracellular Communication and SignalingKnowledgeLeukostasisLeukostasis SyndromeModelingModern ManOrganOrgan failureOutcomePatient AdmissionPatientsPhysiopathologyProteinsRNA ExpressionReactionRecoveryRenal functionResearchResearch SpecimenResolutionRoleSTAT3STAT3 geneSepsisSeptic ShockSeveritiesShockSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSourceSpecimenSyndromeTherapeuticTranscriptionTransgenic MiceVascular DiseasesVascular Disorderantisepsis treatmentbiological signal transductionbleeding disorderblood vessel disordercardiovascular functioncirculatory shockclotting disordercognitive functioncost effectivecytokinecytokine release syndromecytokine stormdesigndesigningdevelopmentaldrivingendothelial dysfunctiongene expression patterngene expression signaturehemodynamicshost responseimmune functionimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimprovedinnovateinnovationinnovativekidney functionmortalitynovelpathogenpathophysiologyposttranscriptionalpreventpreventingresolutionsresponsesepsis caresepsis interventionssepsis managementsepsis therapeuticssepsis therapysepsis treatmentseptic therapyseptic treatmentshockssocial roletooltranscriptional profiletranscriptional signaturetranslatometreat sepsisvascular dysfunctionvasculopathy
Description preview
PROJECT
SUMMARY
Three different fates await the millions of critically ill patients admitted to intensive care units every year. Close to 30%
will recover without obvious sequelae, 15% succumb to the acute illness, and the remainder 55% will develop various
degrees of long-term impairments in cognitive, immune, cardiovascular, or renal functions,…
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