grant
Endogenous retroviruses in autoimmunity: T cell repertoire, tolerance, and disease
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jul 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY202670 kDa zeta-associated proteinAdoptive TransferAffectAllelesAllelism TestAllelomorphsAnti-Retroviral AgentsAntigensArthritisArthritogenicAtrophic ArthritisAutoimmune DiseasesAutoimmune ResponsesAutoimmune StatusAutoimmunityBALB C MouseBALB/cBittner VirusBody TissuesCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell Communication and SignalingCell SignalingCellsCharacteristicsChronicClonalityCollaborationsComplementation TestCustomDNA editorDataDevelopmentDiagnosticDiseaseDisorderDrugsERVsEarly identificationEndogenous RetrovirusesEventGenesGenetic Complementation TestGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGoalsHERVsHealthHumanHuman Endogenous RetrovirusesHuman GenomeImmune TargetingImmune ToleranceImmunologic ToleranceImpairmentInbred BALB C MiceInfiltrationInflammationIntracellular Communication and SignalingJointsKnowledgeMHC ReceptorMMTVMajor Histocompatibility Complex ReceptorMammary Cancer VirusMedicationMiceMice MammalsModern ManMouse Mammary Tumor VirusMurineMusOnset of illnessOutcomePainPainfulPathogenesisPathogenicityPeripheralPharmaceutical PreparationsPilot ProjectsPlayProcessProtein Tyrosine Kinase Zap70Receptor SignalingRecombinant DNA TechnologyRegulatory T-LymphocyteResearchRheumatoid ArthritisRoleSRKSamplingSignal TransductionSignal Transduction SystemsSignalingSingle cell seqSiteSuperantigensSyk-related tyrosine kinaseT cell clonalityT cell infiltrationT cell receptor repertoire sequencingT cell receptor sequencingT-Cell ActivationT-Cell Antigen ReceptorsT-Cell DevelopmentT-Cell OntogenyT-Cell ReceptorT-CellsT-LymphocyteT-Lymphocyte DevelopmentT-cell receptor clonalityT-cell receptor repertoireT4 CellsT4 LymphocytesTCR clonalityTCR repertoireTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTailTestingTherapeutic InterventionThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTrans TestTregVirus IntegrationWild Type MouseZAP-70ZAP-70 GeneZAP-70 KinaseZAP-70 proteinZAP70Zeta-Chain Associated Protein Kinaseactivate T cellsanergyanti-retroviralantiretroviral therapyantiretroviral treatmentarthriticautoimmune arthritisautoimmune conditionautoimmune disorderautoimmune reactivityautoimmunity diseaseautoreactive T cellautoreactivitybiological signal transductioncentral tolerancecomplementation analysiscomplementation approachcustomsdevelopmentaldiagnostic tooldisabilitydisease onsetdisorder onsetdrug/agentexperiencegene editorgenetic approachgenetic strategygenetically engineeredgenome editorglobal gene expressionglobal transcription profilehuman whole genomeimmune system toleranceimmune unresponsivenessimmunogenimmunological paralysisimprovedinflamed jointinsightintervention therapyjoint inflammationjoint swellinglife spanlifespanmammalian genomemammary tumor virusmilk agentmouse modelmurine modelnew diagnosticsnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynext generation diagnosticsnovelnovel diagnosticsnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachperipheral tolerancepilot studypreventpreventingregulatory T-cellsrheumatic arthritisself-reactive T cellsingle cell next generation sequencingsingle cell sequencingsocial rolethymocytethymus derived lymphocytetranscriptomeviral genome integrationviral integrationvirus genome integrationwildtype mouse
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
PROJECT SUMMARY
Rheumatoid Arthritis (RA) is a chronic, destructive autoimmune disease that primarily targets joints. It affects
millions globally and is associated with both disability and reduced lifespan. Antigen-dependent activation of
CD4 T cells contributes to disease onset. However, the specific antigens that activate CD4 T cells and the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click