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Endocrine-mediated pubertal brain network development: Bridging datasets with machine learning
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY202512-20 years oldAddressAdolescenceAdolescentAdolescent YouthAndrogenic AgentsAndrogenic CompoundsAndrogensAndrostenoloneAnimalsApoptosisApoptosis PathwayAquadiolArchitectureAreaAutopsyBRAIN initiativeBehaviorBiological FunctionBiological ProcessBrainBrain DiseasesBrain DisordersBrain Nervous SystemBrain Research through Advancing Innovative Neurotechnologies initiativeCNS plasticityCommunitiesComplementComplement ProteinsContraceptive UsageCorlutinaCorluviteCorpus Luteum HormoneCouplingCyclogestDHEADWI (diffusion weighted imaging)DWI-MRIDataData CollectionData SetDehydroisoandrosteroneDelta4-pregnene-3,20-dioneDendritesDevelopmentDifferences between sexesDiffers between sexesDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDimenformonDiogynDiogynetsEncephalonEncephalon DiseasesEndocrineEndocrine Gland SecretionEngineering / ArchitectureError SourcesEstraceEstradiolEstradiol-17 betaEstradiol-17betaEstraldineEstrogensExhibitsFemale AdolescentsFunctional MRIFunctional Magnetic Resonance ImagingFundingGestagenic AgentsGestagensGestironGestoneGoalsGonadal Steroid HormonesHormone ReceptorHormonesHumanImageIndividual DifferencesIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigationInvestigatorsLeast SquaresLeast-Squares AnalysesLeast-Squares AnalysisLinkLipo-LutinLiteratureLuteohormoneLutocyclinLutocylin MLutogylLutromoneMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentorsModelingModern ManMorphologyNMR ImagingNMR TomographyNeural DevelopmentNeuranatomiesNeuranatomyNeuroanatomiesNeuroanatomyNeurobiologyNeuroendocrineNeuroendocrine SystemNeuroendocrinologyNeuronal PlasticityNeurosecretory SystemsNuclear Magnetic Resonance ImagingOvocyclinOvocylinParticipantPhasePopulationPrasteronePregn-4-ene-3,20-dionePregnenedionePrevalenceProgestagenic AgentsProgestasertProgestational AgentsProgestational CompoundsProgestational HormonesProgesteroneProgesterone AgentsProgestinsProgestogelProgestogensProgestolProgestonProgrammed Cell DeathProgynonProlidonProlutonPsychopathologyPubertyResearchResearch PersonnelResearch ResourcesResearchersResourcesRoleSamplingSex DifferencesSex HormonesSex Steroid HormonesSexual differencesStagingStructureSyngesteroneTechnologyTestingTestosteroneTherapeutic AndrogenTherapeutic DehydroepiandrosteroneTherapeutic EstradiolTherapeutic EstrogenTherapeutic HormoneTherapeutic ProgesteroneTherapeutic ProgestinTherapeutic TestosteroneThickThicknessTimeTrainingTrans-TestosteroneUtrogestanWorkYouthYouth 10-21Zeugmatographyabnormal psychologyadolescence (12-20)adolescent girlbiophysical modelcentral nervous system plasticitycognitive developmentcomplementationcomputer based predictionconnectomecontraceptive usecritical perioddMRIdata integrationdehydroepiandrosteronedesigndesigningdevelopmentaldiffusion tensor imagingexperiencefMRIgirlsgonadal steroidsimagingin vivoinnovateinnovationinnovativeinnovative technologiesinsightjuvenilejuvenile humanmachine based learningmodel generalizabilitynecropsyneuralneural imagingneural mechanismneural plasticityneuro-imagingneurobiologicalneurobiological mechanismneurodevelopmentneuroimagingneurological imagingneuromechanismneuroplasticneuroplasticitynovelpostmortempre-trained modelprecision medicineprecision-based medicinepredictive modelingreceptor expressionrole modelsexsex based differencessex steroidsex-dependent differencessex-related differencessex-specific differencessocial rolesubstantia albatoolwhite matteryouth age
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Description preview
PROJECT SUMMARY
This proposal aims to address the BRAIN Initiative goals of developing and applying technologies for
innovative study of the relationships between biological processes, neural structure, and brain function, to
further our understanding of how sex hormones (e.g., estradiol, testosterone, progesterone) exert organizing
effects on…
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