grant
Endocannabinoid Control of Cholinergic Transmission and the Pursuit of Reward
Organization UNIVERSITY OF MARYLAND BALTIMORELocation BALTIMORE, UNITED STATESPosted 1 May 2025Deadline 28 Feb 2030
NIHUS FederalResearch GrantFY202621+ years oldAD dementiaAcetylcholineAdultAdult HumanAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesAnimalsAreaAssociation LearningAssociative LearningBehaviorBehavior ControlBehavioralBehavioral ManipulationBindingBrainBrain Nervous SystemBrain regionCB1CB1 ReceptorCB1RCNR1 geneCannabinoid Receptor CB1CannabinoidsCell Communication and SignalingCell SignalingCognitionCognitive Retention DisordersComplexCornu AmmonisCoupledDataDetectionDiagonal Band of BrocaDiffusionDiseaseDisorderDistalElectrophysiologyElectrophysiology (science)EncephalonEndocannabinoidsEndogenous CannabinoidsEventExhibitsFeedbackFoodGeneral PopulationGeneral PublicGenerationsHippocampusImmediate MemoryImpairmentInformation RetrievalInformation extractionInfusionInfusion proceduresIntracellular Communication and SignalingLB dementiaLewy Body DementiaLewy Body Type Senile DementiaLewy dementiaLoxP-flanked alleleMeasurementMedialMediatingMemoryMemory DeficitMemory DisordersMemory LossMemory impairmentMiceMice MammalsModificationMolecular InteractionMotivationMotorMurineMusNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeural TransmissionNeurobiologyNeurocyteNeuromodulatorNeuronsNeurophysiology / ElectrophysiologyNeurotransmittersNucleus AccumbensOpticsOutputPartner in relationshipPathway interactionsPavlovian conditioningPerformancePhysiologicPhysiologicalPrefrontal CortexPrimary Senile Degenerative DementiaReceptor ProteinRecoveryRegulationReinforcement ScheduleRewardsRoleSamplingShapesShort-Term MemorySignal TransductionSignal Transduction SystemsSignalingSourceStimulusSynaptic ReceptorsSynaptic TransmissionTechniquesTestingTimeTransmissionVirusadulthoodantagonismantagonistassociative conditioningbasal forebrainbehavior changebehavior responsebehavioral controlbehavioral economicsbehavioral responsebiological signal transductioncannabinoid administrationcannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1cell typecholinergicclassical conditioningdiffuseddiffusesdiffusingdiffusionseCB systemelectrophysiologicalendocannabinoid systemendogenous cannabinoid systemexogenous cannabinoidexperimentexperimental researchexperimental studyexperimentsfloxedfloxed allelegain of functionhippocampalhuman subjectimprovedin vivoinfusionsinnervationmatememory declinememory dysfunctionmemory processmemory processingmodel of animalnerve supplyneuralneurobiologicalneuronalnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachopticaloptogeneticspathwaypresynapticprimary degenerative dementiareceptorrecruitsenile dementia of the Alzheimer typesensorsensory integrationseptohippocampalsexsocial rolespatial navigationtemporal measurementtemporal resolutiontime measurementtransmission processway findingwayfindingwillingness to payworking memory
Description preview
PROJECT SUMMARY
Studies using animal models and human subjects have provided evidence for the importance of acetylcholine
(ACh) in cognition. The medial septum-diagonal band of Broca complex (MS) serves as a significant source of
cholinergic innervation to the hippocampus (HC), a brain region important for memory processes. Cannabinoid
type 1…
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