grant
Enabling systemic delivery of europium-containing contrast agents for magnetic resonance imaging
Organization WAYNE STATE UNIVERSITYLocation DETROIT, UNITED STATESPosted 10 May 2025Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AcidsAddressAirBiochemistryBiodistributionBiological ChemistryBloodBlood Reticuloendothelial SystemCancersChemicalsClinicalComplexContrast AgentContrast DrugsContrast MediaCrystallographiesCrystallographyDataDendrimersDendritic CompoundsDendronsDetectionDevelopmentDiagnosticDiseaseDisorderDissociationElectronsEu elementEuropiumExposure toFundingFutureGlutathioneGoalsHealthHepaticHypoxemiaHypoxiaHypoxicImageInjectionsInvestmentsIonizing Electromagnetic RadiationIonizing radiationKidney DiseasesKineticsKnowledgeLeadLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicineMetalsMethodsMiceMice MammalsMissionMonitorMurineMusNMR ImagingNMR SpectrometerNMR SpectroscopyNMR TomographyNational Institutes of HealthNegative Beta ParticleNegatronsNephropathyNeurologicNeurologicalNuclear Magnetic Resonance ImagingO elementO2 elementOutcomeOxidation-ReductionOxygenOxygen DeficiencyPb elementPhosphatesProliferatingPropertyPublic HealthRadiation-Ionizing TotalRadiopaque MediaRedoxRenal DiseaseResearchResistanceSingle Crystal DiffractionSpectroscopySpectrum AnalysesSpectrum AnalysisTestingTimeToxic effectToxicitiesTranslationsTumor TissueUnited States National Institutes of HealthX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray CrystallographyZeugmatographyarmcontrast enhanceddesigndesigningdevelopmentalgamma-L-Glu-L-Cys-Glygamma-L-Glutamyl-L-Cysteinylglycineheavy metal Pbheavy metal leadhypoxemicimage-based methodimagingimaging agentimaging in vivoimaging methodimaging modalityimprovedin vivoin vivo imaginginnovateinnovationinnovativeinorganic phosphateionizing outputkidney disordermacromoleculemalignancyneoplasm/cancernew drug treatmentsnew drugsnew pharmacological therapeuticnew technologynew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel technologiesnovel therapeuticsnovel therapynuclear magnetic resonance spectroscopyoxidationoxidation reduction reactionphosphonatepre-clinical studypreclinical studypreventpreventingrenal disorderresistantsmall moleculetherapeutic targettooltranslation
Description preview
The ability to image the presence or absence of oxygen is of paramount importance to the study of biochemistry,
medicine, and multiple diseases. Hypoxia is linked to a variety of diseases including kidney disease; hepatic and
neurological toxicities; and the progression, proliferation, and therapy resistance of many cancers, making
hypoxia an…
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