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Enabling risk-based testing through characterization of environmentally induced immune dysregulation and susceptibility to the SARS-CoV2 virus and COVID-19
Organization BURLESON RESEARCH TECHNOLOGIES, INC.Location MORRISVILLE, UNITED STATESPosted 13 Aug 2014Deadline 12 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025AffectAgeAnimalsAntibodiesAntigensAromatic Polycyclic HydrocarbonsAutoimmune DiseasesBlood leukocyteCD28CD28 geneCD3CD3 AntigensCD3 ComplexCD3 moleculeCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCOVID-19COVID-19 antigenCOVID-19 predispositionCOVID-19 susceptibilityCOVID-19 vulnerabilityCV-19Cell-Mediated CytolysisCell-Mediated LympholysisCellular CytotoxicityCellular Immune FunctionChemical AgentsChemicalsCommunicable DiseasesContracting OpportunitiesContractsCoronavirus Infectious Disease 2019Coronavirus disease 2019 predispositionCoronavirus disease 2019 susceptibilityCoronavirus disease 2019 vulnerabilityCytotoxic cellDataDermalDevelopmentDexamethasoneDrugsEnvironmentEnvironmental FactorEnvironmental Risk FactorEthnic OriginEthnicityEventExposure toFemaleFood AdditivesFutureGenderGrippeHealthHealth HazardsHematopoieticHumanHypersensitivityImmuneImmune responseImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic SubtypingImmunologic TechnicsImmunologic TechniquesImmunologicalImmunological TechnicsImmunological TechniquesImmunologicallyImmunologicsImmunomodulationImmunophenotypingImmunosuppressantsImmunosuppressionImmunosuppression EffectImmunosuppressive AgentsImmunosuppressive EffectImmunosuppressive drugImmunosuppressive treatmentImmunotoxicologyIn VitroIndividualInfectious DiseasesInfectious DisorderInfluenzaIntrinsic factorK lymphocyteLeukocytesLeukocytes Reticuloendothelial SystemLiverLymphocyte CytotoxicityLymphocytotoxicityMHC ReceptorMajor Histocompatibility Complex ReceptorManuscriptsMarrow leukocyteMeasuresMediatingMedicationMetabolicMethodsMiceMice MammalsModern ManMolecularMurineMusNK CellsNatural Killer CellsNeoplasmsOKT3 antigenParentsPeptidesPharmaceutical PreparationsPhasePopulationPredictive ValuePredisposed to COVID-19Predisposed to SARS-CoV-2Predisposed to Severe acute respiratory syndrome coronavirus 2PredispositionProbabilistic ModelsProbability ModelsProductionResearchResistanceRiskSARS-CoV-2 antigenSARS-CoV-2 predispositionSARS-CoV-2 susceptibilitySARS-CoV-2 vulnerabilitySamplingSevere acute respiratory syndrome coronavirus 2 predispositionSevere acute respiratory syndrome coronavirus 2 susceptibilitySevere acute respiratory syndrome coronavirus 2 vulnerabilitySolubilityStatistical ModelsStructureSusceptibilitySystemT memory cellT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT3 AntigensT3 ComplexT3 moleculeT44T8 CellsT8 LymphocytesTestingTherapeutic AgentsToxicologyTranslationsViralViral DiseasesVirusVirus DiseasesWhite Blood CellsWhite CellWhole BloodXenobioticsactivate T cellsagesautoimmune conditionautoimmune disorderautoimmunity diseaseburden of diseaseburden of illnesscell mediated cytotoxicitycoronavirus disease 2019coronavirus disease 2019 antigencoronavirus disease-19coronavirus infectious disease-19crosslinkcytokinedevelopmentaldiet supplementdietary supplementsdisease burdendrug/agentenvironmental agentenvironmental riskexperimentexperimental researchexperimental studyexperimentsexposed human populationhemopoietichepatic body systemhepatic organ systemhost responsehuman exposureimmune functionimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive agentimmune suppressive functionimmune suppressorimmune system functionimmune system responseimmunogenimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunosuppressive substanceimmunosuppressorimmunotoxicityin vitro Modelin vivomalememory T lymphocyteneoplasianeoplastic growthnutritional supplementparentperipheral bloodpolyaromatic hydrocarbonspolynuclear aromatic hydrocarbonpredisposed to Coronavirus disease 2019programsresistantrespiratoryresponsesevere acute respiratory syndrome coronavirus 2 antigensexstatistical linear mixed modelsstatistical linear modelssusceptible to COVID-19susceptible to Coronavirus disease 2019susceptible to SARS-CoV-2susceptible to Severe acute respiratory syndrome coronavirus 2toxic reaction in immunologytranslationtrendviral infectionvirus infectionvirus-induced diseasevulnerable to COVID-19vulnerable to Coronavirus disease 2019vulnerable to SARS-CoV-2vulnerable to Severe acute respiratory syndrome coronavirus 2white blood cellwhite blood corpuscle♀♂
Applications closed.
Description preview
In FY FY24 we continued to focus the immunotoxicology research program within the Division of Translation Toxicology (DTT) on in vitro approaches. A major effort involved investigating how interindividual susceptibility factors and environmental risk factors impact the response to viral infection, using an in vitro human whole blood culture…
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