grant
Empowering gene discovery and accelerating clinical translation for admixed populations
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 11 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025AccelerationAccountingAddressAdmixtureAdoptionAffectAll of Us ProgramAll of Us Research ProgramAll of Us Research ProjectAllelesAllelomorphsAmericanAoURPAwardAwarenessBenchmarkingBest Practice AnalysisCell Communication and SignalingCell SignalingClinicalClinical geneticsCollectionComplexComputer Software ToolsComputer softwareDataData CollectionDevelopmentDevelopment PlansDiseaseDisorderDistalDocumentationDysfunctionEffectivenessEnsureEnvironmentEpistasisEpistatic DeviationFrequenciesFunctional disorderGWA studyGWASGenesGeneticGenetic DifferentiationGenetic DivergenceGenetic DiversityGenetic DriftGenetic EpistasisGenetic VariationGenetic studyGenomeGenomic medicineGenomicsGoalsGuidelinesHaplotypesHealthIndividualInteraction DeviationIntracellular Communication and SignalingInvestigatorsLinkage DisequilibriumMapsMedical GeneticsMethodologyMethodsMissionModelingMolecularNHGRINational Center for Human Genome ResearchNational Human Genome Research InstituteNational Institutes of HealthOutcomeOutcome StudyPatternPhasePhenotypePhysiopathologyPopulationPositionPositioning AttributePredicting RiskRecommendationReproducibilityResearchResearch PersonnelResearch ResourcesResearchersResolutionResourcesSample SizeSamplingSignal TransductionSignal Transduction SystemsSignalingSiteSoftwareSoftware ToolsStatistical MethodsStructureTestingTimeTrainingUnited States National Institutes of HealthVariantVariationWorkanalytical methodbenchmarkbiobankbiological signal transductionbiorepositorycareerclinical translationclinically translatablecloud basedcohortcomputational frameworkcomputer frameworkdevelopmentaldiscover genesdisease riskdisorder riskempowermentepistatic interactionepistatic relationshipexperienceflexibilityflexibleforecasting riskgene discoverygene interactiongene x gene interactiongenetic analysisgenetic architecturegenetic elementgenetic epistasesgenome medicinegenome sciencesgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic sciencegenomic toolsimprovedin silicoinnovateinnovationinnovativelarge scale datalarge scale data setslarge scale datasetslow-frequency mutationmolecular targeted therapeuticsmolecular targeted therapiesmolecular targeted treatmentnovelopen sourcepathophysiologypopulation stratificationprecision medicineprecision-based medicinepredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskrare allelerare mutationrare variantresolutionsrisk predictionrisk predictionssimulationsoftware toolkitstatistic methodsstatisticssuccesstooltraittrendwhole genome association analysiswhole genome association study
Description preview
Gene discovery has revolutionized medical genetics, but current methods remain limited in their ability to analyze individuals with complex ancestry profiles. As the U.S. population includes a substantial proportion of individuals with multiple ancestral components, improving analytic methods is essential for maximizing the utility of large-scale…
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