grant
Emergent Multi-Cellular Properties Regulating Pancreatic Islet Function
Organization UNIVERSITY OF COLORADO DENVERLocation Aurora, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2031
NIHUS FederalResearch GrantFY2026AccelerationAdult-Onset Diabetes MellitusB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellB9 endocrine pancreasBeta CellBody TissuesCell BodyCell Communication and SignalingCell DeathCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessCharacteristicsCompensationComputer ModelsComputerized ModelsD-GlucoseDevelopmentDextroseDiabetes MellitusDysfunctionEndocrine PancreasEnvironmentFailureFunctional disorderFundingGenesGeneticGlucoseGoalsHeterogeneityHigh Fat DietHumanHumulin RImageIn VitroInsulinInsulin CellInsulin ResistanceInsulin Secreting CellIntracellular Communication and SignalingIslands of LangerhansIslets of LangerhansKetosis-Resistant Diabetes MellitusKnock-inLeftMaturity-Onset Diabetes MellitusMetabolic stressMiceMice MammalsModern ManMolecularMolecular AnalysisMurineMusNIDDMNR4A2NR4A2 geneNR4A2 proteinNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNur-related factor 1Nurr1Nurr1 nuclear receptorObesityPancreasPancreaticPancreatic IsletsPars endocrina pancreatisPathogenicityPatternPhysiopathologyPopulationPopulation HeterogeneityPredispositionPropertyPublishingRegular InsulinRegulationReporterResearchRoleSignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusStable Diabetes MellitusSubcellular ProcessSusceptibilitySystemT2 DMT2DT2DMTestingTherapeutic AgentsTissuesType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorkadiposityadult onset diabetesbiological signal transductionblood glucose regulationcomputational modelingcomputational modelscomputer based modelscomputerized modelingcorpulencedevelopmentaldiabetesdiverse populationsendocrine cellfirst responderglucose controlglucose homeostasisglucose metabolismglucose regulationheterogeneous populationimagingin vivoinnervationinsulin resistantinsulin secretioninsulin toleranceintra-vital imagingintra-vital microscopyintravital imagingintravital microscopyisletketosis resistant diabetesknockinmaturity onset diabetesnecrocytosisnerve supplynovelnuclear receptor-related factor 1pancreatic islet functionpathophysiologypopulation diversityprogramsresponsesocial roletooltype 2 DMtype II DMtype two diabetesβ-cellβ-cellsβCell
Description preview
PROJECT SUMMARY
Type2 diabetes mellitus (T2DM) is caused by a failure of insulin-secreting 13-cells to secrete sufficient insulin following increased insulin resistance under metabolic stress. During increased insulin demand under metabolic stress 13-cells show adaptation to increase insulin release, which includes increasing the insulin release…
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