grant
Elucidating the structural adaptation of HIV-1 capsids during critical host-factor interactions
Organization FLORIDA STATE UNIVERSITYLocation TALLAHASSEE, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAIDS VirusAIDS/HIVAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffinityAnti-Retroviral AgentsAuthorshipBindingBiologicalBiophysicsCapsidCell BodyCell CommunicationCell InteractionCell NucleusCell Nucleus Active TransportCell-to-Cell InteractionCellsCellular biologyChromatinCollaborationsCompetitive BindingCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyCytoplasmDNA IntegrationDNA mutationDataData CollectionData SetDevelopmentDockingDrug TargetingEC 2.7.7.49ElasticityElectron CryomicroscopyElectron MicroscopyEnvironmentEnzyme GeneEnzymesFluorescence Light MicroscopyFluorescence MicroscopyFreezingGene TranscriptionGeneralized GrowthGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGlobal ChangeGoalsGrowthHIVHIV InfectionsHIV viral infectionHIV virus infectionHIV-1HIV-1 infectionHIV-IHIV/AIDSHIV1Host FactorHost Factor ProteinHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human Immunodeficiency VirusesHuman immunodeficiency virus 1ImageImpairmentIn SituIn VitroInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1IntegraseIntegration Host FactorsInvestigatorsIonsKineticsLAV-HTLV-IIILettersLife CycleLife Cycle StagesLightLocationLymphadenopathy-Associated VirusManuscriptsMapsMediatingMentorsMentorshipMolecularMolecular InteractionMorphologyMutationNPCNational Institutes of HealthNuclearNuclear EnvelopeNuclear ImportNuclear MembraneNuclear Pore ComplexNuclear Pore Complex ProteinsNuclear TransportNucleocytoplasmic ShuttlingNucleoplasmNucleoporin GeneNucleoporinsNucleusNup ProteinPathogenesisPenetrationPhasePhotoradiationPreparationProcessPropertyProteinsPublic HealthPublishingRNA ExpressionRNA TranscriptaseRNA-Dependent DNA PolymeraseRNA-Directed DNA PolymeraseRecombinantsReportingResearch PersonnelResearch ProposalsResearchersResistanceResolutionReverse TranscriptaseReverse TranscriptionRevertaseSamplingScientistShapesSideStructureTOMOTechniquesTechnologyTestingTimeTissue GrowthTomogramTrainingTranscriptionUnited States National Institutes of HealthUtahViralViral DiseasesViral GenomeViral LatencyViral Reverse TranscriptionVirionVirusVirus DiseasesVirus IntegrationVirus LatencyVirus ParticleVirus ReplicationVirus-HIVanti-retroviralbiologicbiophysical foundationbiophysical principlesbiophysical sciencescareercell biologyclinically approved drugclinically approved medicationclinically approved therapeutic agentcombatcompetitively boundconferenceconventioncryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydevelopmentalelectron cryo-tomographyexperiencegenome mutationhigh definitionhigh-resolutionhuman immunodeficiency virus infectionimage processingimaginginfected with HIVinfected with human immunodeficiency virusinsightintegration sitelife courselight microscopylive cell imagelive cell imaginglive cellular imagelive cellular imagingmutantnew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachnucleocytoplasmic transportontogenypreparationspublic health relevanceresistantresolutionsskillsstructural biologystructural imagingstructural mutationstructural variantstructural variationsummitsymposiasymposiumtherapeutic agent developmenttherapeutic developmentthree dimensionaltomographytraffickingundergradundergraduateundergraduate studentviral DNAviral genome integrationviral infectionviral integrationviral multiplicationviral replicationvirologyvirus DNAvirus genomevirus genome integrationvirus host interactionvirus infectionvirus multiplicationvirus-induced disease
Description preview
PROJECT SUMMARY
The HIV-1 capsid provides a protective conical enclosure for the transport of the viral genome to its integration
sites inside the nucleus. The capsid must uncoat to release the newly formed vDNA and to establish a permanent
infection of target cells. When? where? and how? capsids are uncoated remain unclear and hotly debated in…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click