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Elucidating the roles of the beta-2 adrenergic receptor and epidermal growth factor receptor in flavivirus NS1-mediated endothelial dysfunction
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-KinaseAddressAdrenergic ReceptorAdrenoceptorsAgonistBindingBiochemistryBiological ChemistryBloodBlood Reticuloendothelial SystemBlood VesselsBody TissuesBreakbone Fever VirusCaliforniaCatecholamine ReceptorCell BodyCell CoatCell Communication and SignalingCell JunctionsCell SignalingCell Surface GlycoproteinsCellsCellular biologyChicagoClathrinClinical MarkersComplexCoupledDENVDENV infectionDataDengueDengue FeverDengue InfectionDengue VirusDengue diseaseDengue fever virusDengue virus infectionDevelopment PlansDiamondDiseaseDisorderDistalDysfunctionEGF ReceptorEGFRERBB ProteinEndocytosisEndothelial CellsEndotheliumEnvironmentEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor KinaseEpidermal Growth Factor Receptor Protein-Tyrosine KinaseEpidermal Growth Factor-Urogastrone ReceptorsEpinephrine ReceptorsFamilyFlaviviridaeFlavivirusFunctional disorderFutureG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGlycansGlycobiologyGlycocalyxGoalsGroup B ArbovirusGrowth Factor ReceptorsHER1Heparan SulfateHeparitin SulfateHospital AdmissionHospitalizationHost FactorHost Factor ProteinIFNIn VitroInfectionIntegral Membrane ProteinIntegration Host FactorsIntercellular JunctionsInterferonsIntracellular Communication and SignalingIntrinsic Membrane ProteinInvestigationInvestigatorsK22 AwardLinkLipidsLos AngelesMMPsMatrix MetalloproteinasesMediatingMedicalMembraneMembrane GlycoproteinsMentorsMetallopeptidasesMetalloproteasesMetalloproteinasesMiceMice MammalsMolecularMolecular GeneticsMolecular InteractionMurineMusNipah VirusNipah henipavirusNon-structural ProteinNonstructural ProteinOrganOrthoflavivirusOutcomePI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePTK ReceptorsPathogenesisPathogenicity FactorsPathologyPathway interactionsPatientsPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhysiopathologyPolysaccharidesPostdocPostdoctoral FellowProductivityProteinsPtdIns 3-KinasePublic HealthR-Series Research ProjectsR01 MechanismR01 ProgramReceptor ProteinReceptor Protein-Tyrosine KinasesReceptor Tyrosine Kinase GeneReportingResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearch ProposalsResearchersRoleSerotypingSeverity of illnessSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSurface GlycoproteinsTGF-alpha ReceptorTechniquesTestingTissuesToxinTrainingTransactivationTransforming Growth Factor alpha ReceptorTransmembrane ProteinTransmembrane Protein GeneTransmembrane Receptor Protein Tyrosine KinaseTropismType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseTyrosine Kinase Linked ReceptorsTyrosine Kinase ReceptorsUniversitiesUrogastrone ReceptorVaccinationViralViral DiseasesViral PathogenesisVirulence FactorsVirusVirus DiseasesVirus ReplicationWorkadenoreceptorbeta-2 Adrenergic Receptorsbiological signal transductionbreakbone feverc-erbB-1c-erbB-1 Proteincandidate identificationcareercareer developmentcell biologyclinical biomarkersclinically useful biomarkerscytokine release syndromecytokine stormdengue viral infectiondimerdisease severityendothelial dysfunctionerbB-1erbB-1 Proto-Oncogene ProteinerbBlextracellulargraduate studentin vivoin vivo Modelinhibiting antibodyinnate immune mechanismslive cell imagelive cell imaginglive cellular imagelive cellular imagingmembrane structuremosquito-bornemosquitobornenew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathogenpathogenic viruspathophysiologypathwaypost-docpost-doctoralpost-doctoral traineeprotein protein interactionprotein purificationproto-oncogene protein c-erbB-1receptorreceptor mediated endocytosisresearch associatessevere denguesocial rolesrc Kinasessrc Protein-Tyrosine Kinasessrc Tyrosine Kinasessrc-Family Kinasessrc-Family Tyrosine Kinasestherapeutic targettissue tropismtrans-activationundergradundergraduateundergraduate studentuptakevascularviral infectionviral multiplicationviral pathogenviral replicationvirus infectionvirus multiplicationvirus pathogenvirus pathogenesisvirus-induced diseaseβ-2 Adrenoceptorβ2 Adrenergic Receptor
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Description preview
PROJECT SUMMARY/ABSTRACT
Research Project: Dengue virus (DENV) is a medically important pathogen posing a major public health threat.
DENV infection can result in potentially fatal cases of severe dengue associated with vascular leak as a result
of endothelial dysfunction, but the triggers of these pathologies were unknown. We and others have…
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