grant

Elucidating the roles for discrete actin filaments in maintenance of organelle and cellular homeostasis

Organization THOMAS JEFFERSON UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 21 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025Actin FilamentsActin-Binding ProteinActinsAffectAutoregulationBindingBiologyC17orf1C17orf1BCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular MatrixCellular PhysiologyCellular ProcessComplexCytoskeletal SystemCytoskeletonEndoplasmic ReticulumErgastoplasmFMNLFMNL1FMNL1 geneFilamentFutureGoalsHomeostasisHumanIntermediate FilamentsIntracellular Communication and SignalingMaintenanceMammalian CellMediatingMicro-tubuleMicrofilamentsMicrotubulesMitochondriaModern ManMolecular InteractionMyofilamentsOrganellesPathologicPathologyPhysiological HomeostasisPhysiologyPlayPolymersPositionPositioning AttributeProteinsRegulationResearchRoleShapesSignal TransductionSignal Transduction SystemsSignalingStress FibersStructureSubcellular ProcessSystemTherapeutic InterventionWorkbiochemical toolsbiochemistry toolsbiological signal transductionformin-likeformin-like 1intervention therapyintracellular skeletonmitochondrialpolymerpolymericprogramssocial rolespatial and temporalspatial temporalspatiotemporal
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Description preview

Project Summary: The cytoskeleton comprised of the actin filaments, microtubules and the intermediate
filaments plays important roles in organelle dynamics including positioning, transport, and crosstalk. While the
microtubules have been significantly defined for their roles in regulating the dynamics of several organelles
including Endoplasmic…

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Elucidating the roles for discrete actin filaments in maintenance of organelle and cellular homeostasis — THOMAS JEFFERS | Dev Procure