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Elucidating the role of intestinal M cells in rotavirus enteric infection, systemic dissemination, and pathogenesis
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Feb 2024Deadline 31 Jan 2026 β οΈ
NIHUS FederalResearch GrantFY20250-11 years old22-kD Gene Caveolae Protein22kD Caveolae Protein22kD Gene Caveolin 1 Caveolae Protein3-D3-Dimensional3DAffectAgeAlpha Isoform Gene Caveolin 1Antigen-Presenting CellsAntigensApicalAssayAutoregulationBeta Isoform Gene Caveolin 1Biliary AtresiaBioassayBiological AssayBloodBlood Reticuloendothelial SystemBody TissuesBrittle Diabetes MellitusBypassCAV GeneCAV1CAV1 geneCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCapsid ProteinsCas nuclease technologyCaveolaeCaveolasCaveolin 1, Caveolae Protein, 22kDCaveolin ProteinsCaveolin-1 GeneCaveolinsCell BodyCellsCellular ExpansionCellular GrowthCessation of lifeChildChild YouthChildhoodChildren (0-21)ClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCoat ProteinsCy5DeathDetectionDevelopmentDiarrheaDiseaseDisorderElectric ResistanceElectrical ResistanceEndocytosisEnteralEntericEpithelial CellsEpitheliumFITC-dextranFaceFamily suidaeFeverGastroenteritisGenesHarvestHepatic CellsHepatic Parenchymal CellHepatobiliaryHepatocyteHomeostasisHumanIDDMImmuneImmune responseImmunesImmunofluorescence MicroscopyIn VitroIncubatedInfectionInsulin-Dependent Diabetes MellitusIntestinalIntestinal BypassesIntestinesJuvenile-Onset Diabetes MellitusKO miceKetosis-Prone Diabetes MellitusKnock-outKnock-out MiceKnockoutKnockout MiceLabelLifeLinkLiverLiver CellsLoxP-flanked alleleLymphatic TissueLymphoid TissueM cellMeasuresMediatingMediatorMiceMice MammalsModern ManMolecularMurineMusNatureNon-Polyadenylated RNANull MouseOccluding JunctionsOralOrganOrganoidsOrthoreovirusesOut-patientsOutpatientsPancreasPancreaticPancreatic beta CellPancreatic Ξ²-CellPathogenesisPathway interactionsPermeabilityPhysiologicPhysiologicalPhysiological HomeostasisPigsPlaque AssayPlayProcessPyrexiaQuantitative RTPCRQuantitative Reverse Transcriptase PCRRNARNA Gene ProductsRNA SeqRNA sequencingRNAseqReovirusReportingRespiratory Enteric Orphan VirusesRibonucleic AcidRoleRotavirusRotavirus InfectionsRouteSamplingSideSiteSmall IntestinesStructure of beta Cell of isletSudden-Onset Diabetes MellitusSuidaeSurfaceSwineSystemT1 DMT1 diabetesT1DT1DMTestingTight JunctionsTimeTissuesTropismType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVIP21VIP21 GeneVIP21 proteinVaccinesViralViral BurdenViral Coat ProteinsViral GastroenteritisViral LoadViral Load resultViral Outer Coat ProteinViremiaVirionVirusVirus ParticleVisceralVisitVisualizationWorkZonula Occludensaccessory cellagesbacteria pathogenbacterial pathogenbowelcaveolin 1cell growthcell typecyanine dye 5developmentalearly childhoodenteral infectionenteral pathogenenteric infectionenteric pathogenenteric pathogen infectionenteric viral infectionenteric virus infectionenteropathogenenteropathogen infectionenteropathogenic infectionexperimentexperimental researchexperimental studyexperimentsfacesfacialfebrilefebrisfecal samplefloxedfloxed allelefluorescein isothiocyanate dextranfluoresceinthiocarbamoyl dextransfluorescence imagingfluorescent imaginggastrointestinalglobal healthhepatic body systemhepatic organ systemhost responseimmune system responseimmunogenimmunogenicityimmunoresponseimprovedin vivoinfected with enteropathogeninsulin dependent diabetesinsulin dependent type 1intestinal epitheliumintestinal infectionintestinal pathogenintestine bypassintestine infectionintestine pathogenintraperitonealjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteskidsknockout genemonolayermortalitymouse modelmucosal vaccinemurine modelpancreas beta cellpancreas Ξ² cellpancreatic b-cellpathogenpathogenic bacteriapathogenic viruspathwaypediatricporcinepreventpreventingpupqRTPCRrational designsmall bowelsocial rolestool samplestool specimensucklingsuidthree dimensionaltissue tropismtranscriptome sequencingtranscriptomic sequencingtranscytosistype I diabetestype one diabetesuptakevesicular integral membrane protein 21 kDavillinviraemiaviral RNAviral pathogenviral sepsisvirus RNAvirus pathogenvirusemiayoungster
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PROJECT SUMMARY/ABSTRACT
Rotavirus (RV) is the leading cause of viral gastroenteritis in children under the age of 5 globally. Despite the
introduction of several WHO-approved vaccines, RV infections still cause 114 million diarrhea episodes, 24
million outpatient visits, and approximately 215,000 deaths annually, and therefore necessitatesβ¦
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