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Elucidating the Role of C16orf72 in the Cellular Stress Response Network
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Mar 2021Deadline 31 May 2025 ⚠️
NIHUS FederalResearch GrantFY2025Amino AcidsAneuploidAneuploidyBindingBiochemicalBreast CancerBreast Cancer CellBreast Cancer ModelBreast Cancer therapyBreast tumor modelCTXCYCLO-cellCancer Cell GrowthCancer cell lineCancersCarloxanCell BodyCell LineCell SurvivalCell ViabilityCellLineCellsCellular RegulationCellular StressCellular Stress ResponseChemoresistanceCiclofosfamidaCiclofosfamideCicloxalClafenClapheneCo-ImmunoprecipitationsComplexCycloblastinCycloblastineCyclophosphamCyclophosphamideCyclophosphamidumCyclophosphanCyclophosphaneCyclophosphanumCyclostinCyclostineCytophosphanCytophosphaneCytoxanDataDevelopmentDimerizationE3 LigaseE3 Ubiquitin LigaseEndoxanEndoxanaEnduxanFellowshipFosfaseronFundingGeneralized GrowthGenesGeneticGenotoxinsGenoxalGenuxalGoalsGrowthHeat ShockHeat-Shock ReactionHeat-Shock ResponseHeterograftHeterologous TransplantationHomodimerizationHumanHypoxiaHypoxicIndividualL-LysineLedoxinaLysineMalignant Breast NeoplasmMalignant CellMalignant NeoplasmsMalignant TumorMapsMeasuresMediatingMessenger RNAMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMiceMice MammalsMitoxanModelingModern ManModificationMolecularMolecular InteractionMolecular Sieve ChromatographyMurineMusMutagensNeoplasm MetastasisNeosarNutrientOncogenesisOncogenicOxygen DeficiencyPathway interactionsPhenocopyPhenotypePhysiologicPhysiologicalProcytoxProtein DimerizationProteinsProteomePublic HealthResearchResistanceRoleSecondary NeoplasmSecondary TumorSendoxanSeriesSize Exclusion ChromatographyStrains Cell LinesStressStress Response SignalingSyklofosfamidSystemTestingTherapeuticTissue GrowthUbiquitilationUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UbiquitinationUbiquitinoylationWorkXenobioticsXenograftXenograft procedureXenotransplantationZytoxanaminoacidbiological adaptation to stressbreast tumor cellbuild resiliencebuild resiliencycancer cellcancer metastasiscell growth regulationcell stresschemoresistantchemotherapychemotherapy resistancechemotherapy resistantcultured cell linedevelop resiliencedevelop resiliencydevelop therapydevelopmentalempowermentenhance resilienceenhance resiliencyenvironmental stressesenvironmental stressorexperimentexperimental researchexperimental studyexperimentsfacilitate resiliencefitnessgenome scalegenome-widegenomewidegenotoxic agentgenotoxicityimprove resilienceimprove resiliencyimprovedin vivoincrease resilienceincrease resiliencyintervention developmentmRNAmalignancymalignant breast tumormammary cancer modelmammary tumor modelmutantneoplasm/cancernovelontogenypathwaypreventpreventingprogramspromote resiliencepromote resiliencyproteotoxicproteotoxicityreaction; crisisresilience developmentresilient to stressresistantresponsescreeningscreeningssocial rolestress resiliencestress resiliencystress responsestress statestress; reactionstressortherapeutic evaluationtherapeutic testingtherapy developmenttranscriptomicstreatment developmenttumortumor cell metastasistumor growthtumorigenesisubiquinationubiquitin conjugationubiquitin-protein ligasexeno-transplantxeno-transplantation
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PROJECT SUMMARY
A hallmark of cancer is the ability of malignant cells to maintain viability in the face of stressors such as
aneuploidy, nutrient scarcity, and xenobiotic compounds. This multi-stress-resilience phenotype enables tumor
formation, metastasis, and therapy resistance. Individual molecular pathways co-opted by cancer cells to
promote…
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