grant
Elucidating the role of an essential transcription factor in SWI/SNF -mutant rhabdoid tumors
Organization ST. JUDE CHILDREN'S RESEARCH HOSPITALLocation MEMPHIS, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AblationAffectAllelesAllelomorphsAnti-OncogenesAntioncogenesBAF47BAF47 GeneBasal Transcription FactorBasal transcription factor genesBindingBody TissuesCRISPRCRISPR approachCRISPR based approachCRISPR editing screenCRISPR methodCRISPR methodologyCRISPR screenCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based screenCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas systemCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 screenCRISPR/Cas9 technologyCancer BiologyCancer CauseCancer EtiologyCancer Suppressor GenesCancer cell lineCancersCas nuclease technologyCell BodyCell LineCellLineCellsChildhoodChildhood CancersChromatinChromatin Remodeling ComplexChromatin Remodeling FactorClustered Regularly Interspaced Short Palindromic RepeatsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexDNA mutationDataDependenceDiploidDiploidyEmerogenesEnvironmentFamilyGene Action RegulationGene ActivationGene Down-RegulationGene ExpressionGene Expression RegulationGene InactivationGene RegulationGene Regulation ProcessGene SilencingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenetics-MutagenesisGenomicsHigh PrevalenceHistonesINI1INI1 GeneInvestigatorsKnock-outKnockoutLiteratureMalignant CellMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerMapsMating Type Switching/Sucrose Nonfermenting ProteinMeasurementMeasuresMediatingMediatorMentorsMentorshipMethodsModelingMolecular InteractionMutagenesisMutagenesis Molecular BiologyMutateMutationNatureOnco-Suppressor GenesOncogenes-Tumor SuppressorsPolycombProcessProteinsRNA ExpressionRecessive OncogenesRegulator GenesReportingRepressor ProteinsResearch PersonnelResearchersResidualResidual stateRhabdoid SarcomaRhabdoid TumorRoleSMARCB1SMARCB1 geneSNF5SNF5 GeneSNF5L1SNF5L1 GeneSWI/SNF ComplexSWI/SNF Family ComplexSWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 GeneStrains Cell LinesStructureStudy modelsSystemTestingTherapeuticTimeTissuesTrainingTraining ProgramsTranscriptionTranscription ActivationTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscription Factor Proto-OncogeneTranscription Initiation SiteTranscription RepressionTranscription Start SiteTranscription factor genesTranscriptional ActivationTranscriptional Activator/CoactivatorTranscriptional Regulatory ElementsTumor CellTumor Cell LineTumor Suppressing GenesTumor Suppressor GenesWorkcancer cellcancer in a childcancer in childrencancer progressionchild with cancerchildhood malignancychromatin modifierclustered regularly interspaced short palindromic repeats screencultured cell lineearly childhoodgene repressiongenetic trans acting elementgenome mutationgenome scalegenome-widegenomewidehSNF5/INI1 Genehistone modificationinsightmalignancymembermutantneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnoveloncosuppressor genepediatricpediatric cancerpediatric malignancypharmacologicrecruitregulatory generepressor complexscreeningscreeningsskillssocial roletooltrans acting elementtranscription factortranscriptional silencingtumor progression
Description preview
Abstract
Mutations in genes that encode subunits of the SWI/SNF chromatin remodeling complex are observed in nearly
25% of all cancers. Because of this, understanding the mechanisms that lead to cancer progression following
SWI/SNF perturbation has great relevance for our understanding of cancer. Rhabdoid tumors (RTs) provide an
excellent model…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click