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Elucidating the path to type I IFNs in TB infection
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 β οΈ
NIHUS FederalResearch GrantFY2025Antitubercular AgentsBacteriaBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCause of DeathCell BodyCell Communication and SignalingCell SignalingCellsClinical TreatmentClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComplexDataDevelopmentDimensionsDiseaseDisorderELISAER stressEicosanoid ProductionEnzyme-Linked Immunosorbent AssayEpidemicEquilibriumEventExpression SignatureFutureGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfileGene Expression ProfilingGene TranscriptionGeneralized GrowthGeneticGenetic TranscriptionGrowthHistopathologyHumanIFNIL-1IL1ImmuneImmune responseImmunesImmunoblottingImmunologic ReceptorsImmunological ReceptorsInfectionInfection ControlInflammationInflammatory ResponseInhalationInhalingInnate Immune ResponseInterferon Type IInterferonsInterleukin IInterleukin-1Intracellular Communication and SignalingKnowledgeLinkLipidsLiteratureLungLung Respiratory SystemLymphocyte-Stimulating HormoneM tbM tuberculosisM tuberculosis infectionM. tbM. tb infectionM. tuberculosisM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMacrophageMacrophage Cell FactorMeasuresMicroscopyMitochondriaModelingModern ManMolecularMycobacterium tuberculosisMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionMΟOutcomePathogenesisPathogenicityPathway interactionsPatientsPlayProductionProductivityRNA ExpressionRoleSamplingShapesSignal TransductionSignal Transduction SystemsSignalingT Helper FactorTB infectionTB therapyTB treatmentTestingTherapeuticTissue GrowthTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTuberculosisTuberculostatic AgentsWestern BlottingWestern ImmunoblottingWhole OrganismWorkanalyze gene expressionanti-TBanti-tuberculosisantiTBarmbacteria pathogenbacterial pathogenbalancebalance functionbiological adaptation to stressbiological signal transductionclinical interventionclinical therapycytokinedevelopmentaldisseminated TBdisseminated tuberculosisendoplasmic reticulum stressenzyme linked immunoassaygene expression analysisgene expression assaygene expression patterngene expression signaturehost responsehuman diseaseimmune receptorimmune system responseimmunoresponseimprovedin vivoindividual responseindividualized responseinfection due to Mycobacterium tuberculosisinnate immune pathwaysinterestlymphocyte activating factormetabolism measurementmetabolomicsmetabonomicsmitochondrialmouse modelmtbmurine modelnovelontogenypathogenpathogenic bacteriapathwayprotein blottingreaction; crisisrecruitresponsesmall molecular inhibitorsmall moleculesmall molecule inhibitorsocial rolestress responsestress; reactiontherapeutic targettooltranscriptional profiletranscriptional profilingtranscriptional signaturetreat M. tuberculosistreat Mtbtreat Mycobacterium tuberculosistreat tbtreat tuberculosistrial regimentrial treatmenttuberculosis infectiontuberculosis therapytuberculosis treatmenttuberculous spondyloarthropathyuptake
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Description preview
Tuberculosis (TB) is the leading cause of death from infection globally. Our knowledge of the cellular and
molecular events that link inhalation of the causative bacterium, Mycobacterium tuberculosis (Mtb), with either
clearance or productive infection remains limited. The type I interferon (IFN) response is among the first innate
immune responsesβ¦
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