grant
Elucidating the Interplay Between DDX41 and CUX1 Mutations in Hematopoiesis in Danio Rerio and iPSCs
Organization ALBERT EINSTEIN COLLEGE OF MEDICINELocation BRONX, UNITED STATESPosted 1 Dec 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY202521+ years oldAML - Acute Myeloid LeukemiaAML/MDSAccelerationAcute Myeloblastic LeukemiaAcute Myelocytic LeukemiaAcute Myelogenous LeukemiaAdultAdult HumanAnemiaAnti-OncogenesAntioncogenesApoptosisApoptosis PathwayAutomobile DrivingBar CodesBasal Transcription FactorBasal transcription factor genesBiologic ModelsBiological ModelsBirthBloodBlood CellsBlood Precursor CellBlood Reticuloendothelial SystemBlood erythrocyteBone marrow failureBrachydanio rerioCancer Suppressor GenesCell BodyCell Communication and SignalingCell CycleCell Division CycleCell LineageCell SignalingCellsChromatinClinicalClonal ExpansionClonalityColorCoupledCre Lox technologyCre LoxP systemCre lox recombinationCre lox recombination systemCre lox systemCre recombinase/LoxP technologyCre systemDNA DamageDNA Damage RepairDNA HelicasesDNA InjuryDNA RepairDNA Unwinding ProteinsDNA mutationDNA unwinding enzymeDanio rerioDefectDevelopmentDiseaseDisorderDouble-Stranded DNADysfunctionDysmyelopoietic SyndromesElderlyEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEmerogenesErythrocytesErythrocyticErythroid CellsErythroid Precursor CellsErythroid Progenitor CellsErythroid Stem CellsErythropoietic Progenitor CellsErythropoietic Stem CellsEvolutionFamilyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesFunctional disorderGeneHomologGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGenotoxinsGerm LinesGerm-Line MutationGoalsHealthHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematological MalignanciesHematological NeoplasmsHematological TumorHematologyHematopoiesisHematopoieticHematopoietic CancerHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic stem cellsHereditary MutationHeritabilityHeterozygoteHomeo BoxesHomeo DomainHomeoboxHomologHomologous GeneHomologueHumanImpairmentIndividualIntracellular Communication and SignalingInvestigatorsLearningLifeMacrocytic AnemiaMalignant Hematologic NeoplasmMarrow erythrocyteMethodsModel SystemModelingModern ManMutagenesisMutagenesis Molecular BiologyMutagensMutationMyelodysplastic DiseaseMyelodysplastic SyndromesMyelogenousMyeloidOnco-Suppressor GenesOncogenes-Tumor SuppressorsParturitionPathogenesisPatientsPeripheral Blood CellPhysiopathologyPlayPluripotent Stem CellsPredispositionProcessProgenitor CellsProgrammed Cell DeathProliferatingRecessive OncogenesRed Blood CellsRed CellRefractory Anemia with an Excess of BlastsRefractory anaemia with excess blastsRegulationResearch PersonnelResearchersRiskSignal TransductionSignal Transduction SystemsSignalingSmoldering LeukemiaSomatic MutationSusceptibilitySystemTechniquesTherapeuticTrainingTranscription Factor Proto-OncogeneTranscription factor genesTumor Suppressing GenesTumor Suppressor GenesUnscheduled DNA SynthesisWorkZebra DanioZebra FishZebrafishacute granulocytic leukemiaacute myeloid leukemiaacute myeloid leukemia/myelodysplastic syndromeadulthoodadvanced ageage associatedage correlatedage dependentage linkedage relatedage specificbarcodebiological signal transductionblood cell formationblood cell progenitorblood corpusclesblood progenitorblood stem cellblood-forming stem cellcytopeniadevelopmentaldriver lesiondriver mutationdrivingds-DNAdsDNAerythroid differentiationerythroid progenitorerythroid-committed progenitorsexperimentexperimental researchexperimental studyexperimentsflow cytophotometrygenome mutationgenotoxic agentgeriatricgerm-line defectgermline varianthelicasehematopoietic differentiationhematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellheterozygosityhiPSChomeodomainhuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellshuman modeliPSiPSCiPSCsin vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinsightlater in lifelater lifeleukemialoss of functionmodel of humanmosaicmutantmyelodysplasianew diagnosticsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation diagnosticsnext generation therapeuticsnovelnovel diagnosticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoncosuppressor geneparalogparalogous genepathophysiologypluripotent progenitorprogenitor cell differentiationprogenitor cell expansionprogenitor cell modelprogenitor cell proliferationprogenitor differentiationprogenitor expansionprogenitor modelprogenitor proliferationresponsesenior citizensomatic variantstemstem and progenitor cell expansionstem and progenitor cell modelstem and progenitor cell proliferationstem and progenitor differentiationstem cell based modelstem cell derived modelstem cell differentiationstem cell expansionstem cell modelstem cell proliferationstem cell technologystem cellssynergismtranscription factor
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PROJECT SUMMARY
Myelodysplastic syndromes (MDS) are a family of bone marrow failure disorders involving defective
hematopoietic stem and progenitor cells (HSPCs). In MDS, there is clonal expansion of defective HSPCs over
healthy cells, ineffective maturation and uni- or multilineage cytopenias of myeloid lineage cells, and increased
risk of…
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