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Elucidating the causal associations underlying Alzheimer's disease
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Feb 2021Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAPOEAddressAdvisory CommitteesAgeAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease riskAlzheimers DementiaAmentiaAmmon HornAmyloid (Aβ) plaquesAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid PlaquesAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinApo-EApoE proteinApolipoprotein EApplied SkillsAwardAβBig Data AnalyticsBig Data MethodsBig Data ToolsBiologicalBlood VesselsBrain Vascular TraumaCausalityCerebrovascular TraumaCornu AmmonisDegenerative Neurologic DisordersDementiaDevelopmentDiabetes MellitusDiseaseDisease OutcomeDisease ProgressionDisorderEconomic BurdenEducationEducational aspectsEducational workshopElderlyElectronic Health RecordEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiologyEpidemiology ResearchEthicsEtiologyExposure toFeedbackFoundationsGene ExpressionGene variantGeneticGenetic DiversityGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic VariationGenetic propensityGenomicsGenotypeGroups at riskHealthHearing LossHippocampusHypertensionHypoacusesHypoacusisIncidenceIndividualIndividuals from minorityIndividuals of minorityInherited PredispositionInherited SusceptibilityInterventionIntervention StrategiesInvestigatorsKnowledgeLeadershipLife StyleLifestyleLiteratureMT-bound tauMendelian randomizationMental DepressionMentorsMethodologyMethodsMinority GroupsMinority PeopleMinority PopulationMinority individualMolecularNatureNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeuritic PlaquesNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsObesityObservational epidemiologyOutcomeParentsPathogenesisPeople at riskPersonsPersons at riskPhasePhenotypePopulations at RiskPreventionPrimary Senile Degenerative DementiaProteinsProxyRandom AllocationRandom SelectionRandomized, Controlled TrialsResearchResearch PersonnelResearchersRiskRisk FactorsRisk ReductionSenile PlaquesSmokingSocial isolationSocietiesSubgroupTask ForcesTechniquesTestingTherapeutic InterventionTrainingTraining ProgramsVascular Brain InjuryVascular Hypertensive DiseaseVascular Hypertensive DisorderWomanWorkshopa beta peptideabetaadiposityadvanced ageadvisory teamaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging populationallelic variantalzheimer riskamyloid betaamyloid beta plaqueamyloid-b plaqueamyloid-b proteinaβ plaquesbeta amyloid fibrilbiobankbiologicbiorepositorycausationcerebral vascular injurycerebrovascular injurycohortconferenceconventioncored plaquecorpulencedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdepressiondevelopmentaldiabetesdiffuse plaquedisease causationdisease preventiondisorder preventiondysfunctional hearingelectronic health care recordelectronic health medical recordelectronic health plan recordelectronic health registryelectronic medical health recordendophenotypeepidemiologicepidemiologic investigationepidemiologicalepidemiology studyethicalexperiencegenetic analysisgenetic epidemiologic studygenetic epidemiologygenetic etiologygenetic mechanism of diseasegenetic variantgenetic vulnerabilitygenetically predisposedgenomic variantgeriatrichearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthigh blood pressurehippocampalhyperpiesiahyperpiesishypertensive diseasehypertensive disorderintervention therapylack of physical activitylife style interventionlife-style factorlifestyle factorslifestyle interventionmalleable riskmicrotubule bound taumicrotubule-bound taumodifiable riskneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneuropathologicneuropathologicalneuropathologynoveloffspringp-taup-τparentphenomephospho-tauphospho-τphosphorylated tauphysical inactivitypolygenetic risk scorespolygenic risk scorepopulation agingpopulation stratificationpost-translational modification of tauposttranslational modification of taupreventpreventingprimary degenerative dementiaprogramspsychosocialrandomized control trialreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrisk-reducingsenile dementia of the Alzheimer typesenior citizensexskillssoluble amyloid precursor proteinsuccessful interventionsummitsymposiasymposiumtangletautau Proteinstau factortau phosphorylationtau posttranslational modificationtau-1traitvascularτ Proteinsτ phosphorylation
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Project Summary
Alzheimer’s disease (AD) is a global crisis facing the aging population and society as a whole. With the number
of people living with AD predicted to rise dramatically in the coming decades, it is imperative to pursue research
that aims to reduce the expected incidence of dementia, such as identifying modifiable risk factors for…
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