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Elucidating roles and mechanisms of double-stranded RNA-mediated pathways

Organization UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAHLocation SALT LAKE CITY, UNITED STATESPosted 1 Apr 2021Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025AnimalsAnti-viral ResponseBinding ProteinsBiochemicalBiochemistryBiological ChemistryC elegansC. elegansC.elegansCaenorhabditis elegansDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDeaminationDicer EnzymeDouble-Stranded RNAEnabling FactorsEnzyme GeneEnzymesGene InactivationGene SilencingGenetic ScreeningGoalsHealthHumanIFNImmuneImmune responseImmunesIn VitroIn vivo analysisInnate Immune ResponseInterferonsInvertebrataInvertebratesKineticsKnowledgeLigand Binding ProteinLigand Binding Protein GeneMammaliaMammalsMediatingModern ManMolecularMolecular MotorsNon-Polyadenylated RNAPathway interactionsPost-Transcriptional Gene SilencingProcessProtein BindingProteinsRNARNA EditingRNA Gene ProductsRNA InterferenceRNA Interference PathwayRNA SilencingRNA, Messenger, EditingRNAiResearchRibonucleic AcidRoleSequence-Specific Posttranscriptional Gene SilencingSiteSmall RNAVertebrate AnimalsVertebratesViraladenosine deaminase that acts on RNAbound proteindADARdesigndesigningdouble-stranded RNA-specific adenosine deaminasedsRNAdsRNA adenosine deaminasedsRNA-specific adenosine deaminasefascinatehelicasehost responseimmune system responseimmunoresponsein vivo evaluationin vivo testinginsightmodel organismpathwaysocial rolestructural biologytranscriptional silencingvertebrataviral RNAvirus RNA

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Description preview

SUMMARY/ABSTRACT
The goal of the proposed research is to define and characterize the long double-stranded RNA (dsRNA) encoded

and expressed in animals, including humans, and the proteins that bind, modify, and process this dsRNA. A key,

health-related, focus is how this endogenous dsRNA is discriminated from the long viral dsRNA that is recognized…

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Elucidating roles and mechanisms of double-stranded RNA-mediated pathways β€” UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSI | Dev Procure