grant
Elucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment Disorders
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 15 Aug 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20253-D modeling3D modelingAreaAtlasesAutomobile DrivingAwarenessBRAIN initiativeBasal Transcription FactorBasal transcription factor genesBioinformaticsBody SystemBrainBrain Nervous SystemBrain Research through Advancing Innovative Neurotechnologies initiativeCRISPR activationCRISPR activatorCRISPR based activationCRISPR gene activationCRISPR transcription activationCRISPR transcriptional activationCRISPR-Cas-9-mediated gene activationCRISPR-based gene activationCRISPR-dCAS9 ActivatorCRISPR-mediated transcriptional activationCRISPR/CAS9 activationCRISPR/CAS9 gene activationCRISPR/dCas9 activationCRISPR/dCas9-based transcriptional activationCRISPRaCausalityCell BodyCell Communication and SignalingCell DensityCell Fate ControlCell Fate RegulationCell SignalingCellsCerebral cortexCognitionComplexConsciousConsciousnessData SetDecision MakingDevelopmentDiseaseDisorderEncephalonEtiologyEvaluationEventExpression SignatureFoundationsGene Expression ProfileGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGeneticGenetic TranscriptionGoalsHumanHuman DevelopmentIndividualIntracellular Communication and SignalingJudgmentKnowledgeMaintenanceMeasuresMethodsModelingModern ManMolecularNerve CellsNerve UnitNeural CellNeural DevelopmentNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsOrgan SystemOrganoidsPatternPerceptionPhenotypePrefrontal CortexPublishingRNA ExpressionRodentRodentiaRodents MammalsRoleSeminalSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedStudy modelsSurvey InstrumentSurveysSystemTestingTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesWorkactivating CRISPR technologybio-informatics toolbioinformatics toolbiological signal transductioncandidate identificationcausationcell cortexcell fate specificationcell typecognitive taskcritical perioddesigndesigningdevelopmentaldisease causationdrivingempowermentexperimentexperimental researchexperimental studyexperimentsgene expression patterngene expression signatureimprovedinnovateinnovationinnovativeinterestknock-downknockdownneurodevelopmentneurodevelopmental diseaseneurogenesisneuronalneuropsychiatric diseaseneuropsychiatric disordernoveloverexpressoverexpressionprogenitor cell modelprogenitor modelprogramsquery toolsscRNA sequencingscRNA-seqsensory inputsensory integrationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelthree-dimensional modelingtooltranscription factortranscriptional profiletranscriptional signaturevirtual
Description preview
PROJECT SUMMARY
The human brain has an expanded cortex compared to its closest relatives, and this outer layer of the brain
provides humans with complex functions including integration of sensory inputs, judgement, and conscious
decision making. Each of these areas of the cortex contains unique cell types, density of cells across layers,…
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