grant
Elucidating physiology of dormant bacteria to combat antibiotic persistence
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Sept 2020Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AddressAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAssayAwardBacteriaBacterial InfectionsBioassayBiological AssayBiomassBiophysical ProcessBudgetsC diffC difficileC. diffC. difficileCF infectionCF patientsCell BodyCell Death ProcessCellsClostridioides difficileClostridium difficileContracting OpportunitiesContractsCytoplasmDataDeveloped CountriesDevelopmentDrug TargetingGeneralized GrowthGenesGram-Negative BacteriaGrowthIR/UV/Raman SpectroscopyIndividualIndustrialized CountriesIndustrialized NationsIonsKnock-outKnockoutLaboratoriesM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMTB infectionMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMath ModelsMeasuresMicrobial BiofilmsMicrofluidicsMicroscopyMiscellaneous AntibioticMolecularMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNutrientOrganism-Level ProcessOrganismal ProcessOsmotic PressureP aeruginosaP. aeruginosaP. aeruginosa infectionPathogenicityPathway interactionsPermeabilityPhasePhenotypePhysiologic ProcessesPhysiological ProcessesPhysiologyProcessProteinsProteomicsPseudomonas aeruginosaPseudomonas aeruginosa infectionPseudomonas pyocyaneaRaman SpectroscopyRaman Spectrum AnalysisRaman imagingRaman spectrometryResearchResistance to antibioticsResistant to antibioticsRibosomal RNARoleSodium ChlorideStarvationTB infectionTechniquesTimeTissue GrowthTuberculosisUrinary tract infectionUrinary tract infectious diseaseWorkantibiotic drug resistanceantibiotic resistantantibiotic tolerancebacteria infectionbacterial diseasebiofilmbiophysical mechanismcell envelopecombatcystic fibrosis infectioncystic fibrosis patientsdensitydeveloped countrydeveloped nationdeveloped nationsdevelopmentaldisseminated TBdisseminated tuberculosisfemale infectionsgenetic resistanceindividuals with CFindividuals with cystic fibrosisinfected femalesinfected with P. aeruginosainfected with Pseudomonas aeruginosainfected womeninfection due to Mycobacterium tuberculosisinfection in CFinfection in cystic fibrosisinfection recurrenceinfections among womeninfections in femalesinfections in womeninnovateinnovationinnovativeinsightmathematic modelmathematical modelmathematical modelingmodel organismmutantnovelontogenypathogenpathwaypatients with CFpatients with cystic fibrosispressurerRNArecurrent infectionrecurring infectionsaltsocial roletolerance to antibioticstolerate antibioticstuberculosis infectiontuberculous spondyloarthropathyurinary infectionwomen experiencing infectionswomen infectionswomen with infectionsµfluidic
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PROJECT SUMMARY
The vast majority of antibiotics are ineffective at killing non-growing bacteria and it is estimated that 50% of antibiotic
tolerance cases are due to phenotypic ‘persistence’ rather than genetic resistance. Common examples of recurrent infections
include urinary tract infections of pathogenic E. coli—the most common bacterial…
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