grant
Elucidating mechanisms underlying replication checkpoint control
Organization UNIVERSITY OF TX MD ANDERSON CAN CTRLocation HOUSTON, UNITED STATESPosted 16 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025ATP-protein phosphotransferaseAddressAnti-Cancer AgentsAntineoplastic AgentsAntineoplastic DrugsAntineoplasticsBM28BindingCDCL1CHEK1CHEK1 geneCHK1Cancer DrugCancer GenesCancer TreatmentCancer-Promoting GeneCell BodyCell Communication and SignalingCell CycleCell Cycle CheckpointCell Cycle ControlCell Cycle ProgressionCell Cycle RegulationCell Devision Cycle-Like 1Cell Division CycleCell Growth in NumberCell LineCell MultiplicationCell ProliferationCell SignalingCell SurvivalCell ViabilityCell-Cycle Checkpoint KinaseCellLineCellsCellular ProliferationCheckpoint inhibitorCheckpoint kinase 1Chemotherapy and RadiationChemotherapy and/or radiationClinical TrialsDNADNA DamageDNA Damage RepairDNA HelicasesDNA InjuryDNA RepairDNA ReplicationDNA Replication InitiationDNA SynthesisDNA Unwinding ProteinsDNA biosynthesisDNA lesionDNA replication forkDNA unwinding enzymeDefectDeoxyribonucleic AcidETAA1EnsureEventEwing's Tumor associated antigen 1Ewing's tumor associated antigenGEM modelGEMM modelGenetically Engineered MouseGenomeGoalsHypothetical Protein KIAA0259 GeneImmune checkpoint inhibitorIntracellular Communication and SignalingKIAA0259 GeneKinase Family GeneKinasesLeadLesionM PhaseMCM2MCM2 geneMaintenanceMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMediatingMetabolic Protein DegradationMinichromosome Maintenance Complex Component 2MitosisMitosis StageMitotinMolecularMolecular InteractionMonitorNeoplastic Disease Chemotherapeutic AgentsNuclear Protein BM28OncogenesPathway interactionsPb elementPhosphorylationPhosphotransferase GenePhosphotransferasesPlayPolymeraseProcessProliferatingProtein KinaseProtein PhosphorylationProtein TurnoverProteinsRadiationRadiation Induced DNA DamageRadiation Induced GenotoxicityRegulationRegulatory Protein DegradationReplication InitiationRoleS PeriodS phaseSS DNA BPSignal TransductionSignal Transduction SystemsSignalingSingle-Stranded DNASingle-Stranded DNA-Binding ProteinStrains Cell LinesStructureSynthesis PeriodSynthesis PhaseSystemTOPBP1TOPBP1 GeneTestingTopoisomerase (DNA) II Binding Protein GeneTransforming GenesTransphosphorylasesTumor-Specific Treatment AgentsUnscheduled DNA SynthesisWorkanti-cancer druganti-cancer therapybiological signal transductioncancer therapycancer-directed therapycell cycle check pointcell-cycle check point kinasecheck point kinase 1chemo/radiation therapychemotherapeutic agentchemotherapeutic compoundschemotherapeutic drugschemotherapeutic medicationschemotherapy and radiotherapychk1 kinasechk1 protein kinasecultured cell lineestablished cell linegenetically engineered mouse modelgenetically engineered murine modelgenome integritygenomic integrityglycogen synthase a kinaseheavy metal Pbheavy metal leadhelicasehydroxyalkyl protein kinaseimmune check point inhibitorinhibitorpathwayphosphorylase b kinase kinasepreventpreventingprotein degradationprotein functionradiation damage to DNAradiation or chemotherapyradiation-induced DNA breaksrecruitreplication forkreplication stressresponsesocial rolessDNAupstream kinase
Description preview
PROJECT SUMMARY
The maintenance of genomic integrity after DNA damage and replication stress depends on the coordination of
DNA repair and cell cycle checkpoints. The replication checkpoint pathway, which comprises two critical
protein kinases, ATR and CHK1, has an essential role in this coordination. Inhibition of the replication
checkpoint…
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