grant
Elucidating mechanisms regulating Treg tissue responses driven by IL-33 in the lung
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026ARDSATAC sequencingATAC-seqATACseqAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAddressAdoptive Cell TransfersAdrenal Cortex HormonesAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAllogenicAlveolarAlveolar MacrophagesAmphiregulinApoplexyAssay for Transposase-Accessible Chromatin using sequencingAutologousAutomobile DrivingAutoregulationBALB C MouseBALB/cBasal Transcription FactorBasal transcription factor genesBindingBioinformaticsBlood SerumBlood capillariesBlood monocyteBody TissuesBrain Vascular AccidentCRGFCell BodyCell Communication and SignalingCell SignalingCell TherapyCell secretionCellsCellular SecretionCellular biologyCellular immunotherapyCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChIP SequencingChIP-seqChIPseqChemicalsClinicalClinical TreatmentCo-StimulatorCollaborationsColorectum Cell-Derived Growth FactorCommunicable DiseasesCorticoidsCorticosteroidsCostimulatorCritical CareDNA Molecular BiologyDa Nang LungDataDevelopmentDrug TherapyEffectivenessEngineeringEpidermal Thymocyte Activating FactorEpitheliumEquilibriumExonsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFosteringFoundationsFrequenciesGeneral Transcription Factor GeneGeneral Transcription FactorsGenesHomeostasisHourIL-13IL-2IL13IL2 ProteinImmuneImmune infiltratesImmunesImmunologyImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapeutic agentImpairmentInbred BALB C MiceIndustryInfectious DiseasesInfectious DisorderInflammationInflammatoryInjuryInterleukin 2Interleukin 2 PrecursorInterleukin IIInterleukin-13Interleukin-2Interleukine 2Interleukine 2 PrecursorInterleukine IIInterleukinsIntracellular Communication and SignalingInvestigationInvestigatorsIsoformsKeratinocyte-Derived Autocrine FactorKnock-outKnockoutLifeLungLung InflammationLung Respiratory SystemLung Tissue FibrosisLung damageLung tissue regenerationLymphocyte Mitogenic FactorMacrophageManuscriptsMapsMarrow monocyteMediatingMembraneMentorshipMiceMice MammalsMitogenic FactorModelingMolecular BiologyMolecular InteractionMorbidityMurineMusMuscleMuscle TissueMφNGS MethodNGS systemO elementO2 elementOrganOutcomeOxygenPathologyPharmacological TreatmentPharmacotherapyPhysiological HomeostasisPlayPneumonitisPreparationPromoter RegionsPromotor RegionsProtein IsoformsPulmonary FibrosisPulmonary InflammationPulmonary MacrophagesRNA SeqRNA sequencingRNAseqReceptor ProteinRegenerative MedicineRegulationRegulatory ElementRegulatory T-LymphocyteResearch PersonnelResearchersResolutionRoleSchwannoma-Derived Growth FactorSerumShock LungSignal TransductionSignal Transduction SystemsSignalingSortingSourceStiff lungStrokeSurfaceSurvivorsT cell based immune therapyT cell based therapeuticsT cell based therapyT cell directed therapiesT cell growth factorT cell immune therapyT cell immunotherapyT cell responseT cell targeted therapeuticsT cell therapyT cell treatmentT cell-based immunotherapyT cell-based treatmentT cellular immunotherapyT cellular therapyT lymphocyte based immunotherapyT lymphocyte based therapyT lymphocyte therapeuticT lymphocyte treatmentT-Cell Growth FactorT-Cell ProliferationT-Cell Stimulating FactorT-cell therapeuticsT-cell transfer therapyTechniquesTestingTherapeuticThymocyte Stimulating FactorThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissuesTrainingTranscription Factor Proto-OncogeneTranscription factor genesTransgenic MiceTranslational ResearchTranslational ScienceTransplantationTregViralViral VectorWorkadoptive T cell transferadoptive T lymphocyte transferadoptive T-cell therapyadoptive cell therapyadoptive cellular therapyantagonismantagonistassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbalancebalance functionbiological signal transductionbrain attackcapillarycareercell based interventioncell biologycell engineeringcell mediated interventioncell mediated therapiescell-based immunotherapycell-based therapeuticcell-based therapycellular engineeringcellular therapeuticcellular therapycerebral vascular accidentcerebrovascular accidentchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingclinical careclinical interventionclinical therapycolorectal cell-derived growth factorcolorectal-associated growth factorcolorectum-associated growth factorcomparable efficacycomparative efficacycompare efficacyconferenceconventiondetermine efficacydevelopmentaldisease modeldisorder modeldrivingdrug interventiondrug treatmenteffective therapyeffective treatmentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationengineered T cellsevaluate efficacyexamine efficacyfibrosis in the lungflow cytophotometrygenetic promoter elementgenetic promoter sequencegenetically engineered T-cellsimmune cell infiltrateimmune cell therapyimmune drugsimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune-based therapeuticsimmunologic reactivity controlimmunologic therapeuticsimmunomodulatoryimmunoregulationimmunoregulatoryimmunosuppressive activityimmunosuppressive functionimmunosuppressive responseimmunotherapeuticsimmunotherapy agentimprovedimproved outcomeinjuriesinjury recoveryinjury responseinjury to tissueinsightinterestkeratinocyte autocrine factorlong-term sequelaelung fibrosislung functionlung injurylung regenerationlung repairlung tissue repairmanufacturemanufacturing processmembrane structuremonocytemortalitymuscularnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext gen sequencingnext generation sequencingnext generation therapeuticsnextgen sequencingnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspre-clinicalpre-clinical studypreclinicalpreclinical studypreparationspreventpreventingprogenitor cell proliferationprogenitor proliferationpromoterpromoter sequencepromotorpulmonary damagepulmonary functionpulmonary injurypulmonary regenerationpulmonary repairpulmonary tissue damagepulmonary tissue injuryreceptorrecovery after injuryrecovery following injuryrecovery post injuryregulatory T-cellsrepairrepair functionrepairedreparative functionresolutionsresponseresponse to injuryrestorationsocial rolestem and progenitor cell proliferationstem cell proliferationstrokedstrokessummitsymposiasymposiumtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic T-cell platformtissue injurytissue repairtranscription factortranscriptome sequencingtranscriptomic sequencingtransgenic T- cellstranslation researchtranslational investigationtranslational medicinetransplanttrial regimentrial treatmentventilationwet lung
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PROJECT SUMMARY/ABSTRACT
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are life-threatening
conditions that result from direct or indirect lung damage, leading to uncontrolled inflammation, alveolar injury,
and impaired oxygen exchange and impaired lung repair. Despite advancements in clinical care,…
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