grant

Elucidating Immune and Microglial Dynamics in Alzheimer's Disease with Advanced Organoid Models.

Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Sept 2020Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2025AD dementiaAffectAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease riskAlzheimers DementiaBiochemicalBiological FunctionBiological ProcessBody TissuesBrainBrain Nervous SystemCare GiversCaregiversCell BodyCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelChemicalsClinical TrialsComplementComplement ProteinsDataDegenerative Neurologic DisordersDeteriorationDevelopmentDiseaseDisease ProgressionDisorderDisparateDysfunctionEncephalonEnvironmentFailureFunctional disorderGWA studyGWASGene ModifiedGenesGeneticGenetic RiskGenetic predisposing factorGoalsHealthHealth Care CostsHealth CostsHumanImmuneImmunesImmunoblottingInduced pluripotent stem cell derived neuronsLeadLinkMediatingMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsModelingModern ManNAC precursorNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurofibrillary TanglesNeurologic Degenerative ConditionsNeuron DegenerationNeuron from iPSCNeuron from induced pluripotent stem cellsOrganoidsPARK1 proteinPARK4 proteinParalysis AgitansParkinsonParkinson DiseasePathogenesisPathologicPathologyPathway interactionsPatientsPb elementPersonsPhysiologicPhysiologicalPhysiopathologyPostdocPostdoctoral FellowPrimary ParkinsonismPrimary Senile Degenerative DementiaPropertyProtein SecretionProteinsProteomicsQOLQOL improvementQuality of lifeR-Series Research ProjectsR01 MechanismR01 ProgramRNA SeqRNA sequencingRNAseqRegenerative capacityResearchResearch AssociateResearch GrantsResearch Project GrantsResearch ProjectsRisk-associated variantRodentRodentiaRodents MammalsRotenoneSNCASNCA proteinStaining methodStainsStimulusSubcellular ProcessTechniquesTestingTherapeutic InterventionTimeTissuesToxic effectToxicitiesTranslatingVariantVariationVascularizationWestern BlottingWestern Immunoblottinga-syna-synucleinalpha synucleinalpha synuclein genealphaSP22alzheimer riskasyncell typecombatcomparativecomplementationconditioningcostdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaldifferential expressiondifferentially expresseddisease modeldisorder modelgene modificationgenetic associationgenetic risk factorgenetically modifiedgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studyglobal gene expressionglobal transcription profileheavy metal Pbheavy metal leadhuman subjectiPSiPS neuronsiPSCiPSC derived-neuronsiPSCsimprovedimprovements in QOLimprovements in quality of lifeinduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cell neuronsinducible pluripotent cellinducible pluripotent stem cellinherited factorinterestintervention therapymesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmultipotent cellnerve cell deathnerve cell lossneuralneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurofibrillary degenerationneurofibrillary lesionneurofibrillary pathologyneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneurons derived from induced pluripotent stem cellsneurons differentiated from induced pluripotent stem cellsnon A-beta component of AD amyloidnon A4 component of amyloid precursorparacrinepathophysiologypathwaypost-docpost-doctoralpost-doctoral traineepost-doctoral trainingpreventpreventingprimary degenerative dementiaprotein blottingquality of life improvementregeneration abilityregeneration capacityregenerativeresearch associatesrisk allelerisk generisk genotyperisk locirisk locusrisk variantsenile dementia of the Alzheimer typesymptom treatmentsymptomatic treatmentsynucleinopathytangletherapeutic targettranscriptional differencestranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstreat symptomwhole genome association analysiswhole genome association studyα synuclein geneα-synα-synuclein
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
— or —

Get email alerts for similar roles

Weekly digest · no password needed · unsubscribe any time

Description preview

Parkinson’s disease (PD) is the second most common neurodegenerative condition, with serious negative impacts on quality of life, as well as financial and personal burden on sufferers and caregivers. There remains no disease modifying therapy. PD is strongly linked to aberrant oligomerization and accumulation of alpha-synuclein (αsyn) protein.…

🔒

Full details available on the Agency plan

Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.

Start 7-day free trial — $29.99/mo →

Agency Plan

7-day free trial

Unlock procurement & grants

Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.

$29.99 / month

  • 🔔Email alerts for new matching tenders
  • 🗂️Track tenders in your pipeline
  • 💰Filter by contract value
  • 📥Export results to CSV
  • 📌Save searches with one click
Start 7-day free trial →

Explore more

📍 More grants in UNITED STATES🏷 More NIH opportunities🏷 More US Federal opportunities🏷 More Research Grant opportunities🏢 All nih_reporter opportunities
Elucidating Immune and Microglial Dynamics in Alzheimer's Disease with Advanced Organoid Models. — UNIV OF NORTH CAROLIN | Dev Procure