grant
Elucidating a novel respiratory-mammary axis of T cell immunity
Organization SEATTLE CHILDREN'S HOSPITALLocation SEATTLE, UNITED STATESPosted 16 Dec 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20260-11 years old2019 novel corona virus2019 novel coronavirus2019-nCoVActive Follow-upAcuteAdvisory CommitteesAirway infectionsAntibodiesAntigensAwardBody TissuesBreastBreast FeedingBreast MilkBreastfed infantBreastmilkCOVID-19 virusCOVID19 virusCell BodyCell Mediated ImmunologyCell-Mediated ImmunityCellsCellular ImmunityCellular biologyChildChild YouthChildhoodChildren (0-21)ClinicCoV-2CoV2Computational BiologyDataEnrollmentExhibitsExposure toFacultyFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesFutureGene TranscriptionGenetic TranscriptionGestationGlycoproteinsGoalsHomingHuman MilkHuman Mother's MilkImmune GlobulinsImmunityImmunochemical ImmunologicImmunoglobulinsImmunologicImmunologic SubtypingImmunologicalImmunologicallyImmunologicsImmunophenotypingIncidenceInfantInfectionInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AIntramuscularLactationLifeMHC ReceptorMajor Histocompatibility Complex ReceptorMammary Gland MilkMaternal ExposureMemoryMentorshipMother's MilkMothersMucosaMucosal TissueMucous MembraneNasal MucosaNursing infantOrthomyxovirus Type APBMCParticipantPeptidesPeripheral Blood Mononuclear CellPhenotypePopulationPositionPositioning AttributePostpartum PeriodPregnancyProcessProliferatingPulmonary Body SystemPulmonary Organ SystemRNA ExpressionRSV VaccinesRSV infectionReceptors, Antigen, T-Cell, alpha-betaResearchResearch DesignResearch InstituteResearch SpecimenRespiratory InfectionsRespiratory Syncytial Virus InfectionsRespiratory Syncytial Virus VaccinesRespiratory SystemRespiratory Tract InfectionsRespiratory TractsRespiratory infectious agentRespiratory syncytial virusRespiratory tract pathogenRespiratory tract structureRiskRoleSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SalivaSamplingSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2SeveritiesSpecimenStructure of mucous membrane of noseStudy TypeT cell infiltrationT cell responseT memory cellT-Cell ActivationT-Cell Antigen ReceptorsT-Cell ReceptorT-Cell SubsetsT-CellsT-LymphocyteT-Lymphocyte SubsetsTask ForcesTcR alpha-betaTcR αβTechnologyTestingTissuesTranscriptionType A InfluenzaUpper Respiratory InfectionsUpper Respiratory Tract InfectionUpper respiratory tractVaccinationVaccinesViral Respiratory Tract InfectionWomanWorkWuhan coronavirusactivate T cellsactive followupacute infectionadvisory teamalpha-beta T-Cell Receptoranti-microbialantimicrobialbreastfeeding infantcare seekingcareercell bankcell biologycohortcomputer biologycoronavirus disease 2019 viruscoronavirus disease-19 virusempowermentenrollflow cytophotometryfollow upfollow-upfollowed upfollowuphCoV19human studyimmunogeninfancyinfant infectioninfantileinfected infantkidslactatinglactationalmammarymaternal milkmemory T lymphocytenCoV2novelpathogenic viruspediatricperipheral bloodpost-partumprogramsrecruitresidenceresident memory T cellresidential buildingresidential siterespiratoryrespiratory pathogenresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskillssocial rolestudy designsuccessthymus derived lymphocytetissue resident memory T cellupper airway tracturgent careviral pathogenviral respiratory infectionvirus pathogenyoungsterαβ T-Cell Receptor
Description preview
Breastfeeding is associated with immunological benefits that persist beyond infancy, including reduced risk of
respiratory infection. While these benefits are often attributed to immunoglobulins and antimicrobial compounds,
human milk is also rich in T cells whose function is unknown. A central goal of my research career is to elucidate
the…
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