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EHD1-mediated Inflammation and Resolution in Atherosclerosis

Organization ICAHN SCHOOL OF MEDICINE AT MOUNT SINAILocation NEW YORK, UNITED STATESPosted 1 May 2023Deadline 10 Aug 2025 ⚠️
NIHUS FederalResearch GrantFY2025ASCVDAddressAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoptoticAreaArterial Fatty StreakAtherogenicityAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseAutophagocytosisC-terminalCardiacCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCause of DeathCell BodyCell FunctionCell PhysiologyCell ProcessCell surfaceCellsCellular FunctionCellular PhysiologyCellular ProcessCholesterolChronicClinicalDataDiseaseDisorderEPH- and ELK-Related Tyrosine KinaseEPH-and ELK-Related KinaseEnzyme GeneEnzymesEphrin Type-A Receptor 8Ephrin Type-A Receptor 8 PrecursorEventGene ExpressionGoalsHeart VascularHumanHuman GeneticsImmune responseImpairmentIn VitroInflammationInflammatoryInflammatory ResponseIntegral Membrane ProteinInterruptionIntrinsic Membrane ProteinInvestigatorsLesionLinkLipidsLipoproteinsMacrophageMediatingMediatorMembraneMetallopeptidasesMetalloproteasesMetalloproteinasesMiceMice MammalsModern ManMurineMusMyelogenousMyeloidMφNecrosisNecroticPathway interactionsPersonsPhenotypePlaque RupturePlayPopulationPositionPositioning AttributeProcessProtein FamilyProtein Tyrosine KinaseProtein Tyrosine Kinase EEKProteinsRNA SeqRNA sequencingRNAseqReceptor ProteinRecyclingResearchResearch PersonnelResearchersResidualResidual stateResolutionRiskRoleSubcellular ProcessTestingTherapeuticTransmembrane ProteinTransmembrane Protein GeneTyrosine KinaseTyrosine-Protein Kinase Receptor EEKTyrosine-Specific Protein KinaseTyrosylprotein Kinaseatheromatosisatherosclerosis plaqueatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic plaque ruptureatherosclerotic vascular diseaseautophagycardiovascular disordercardiovascular riskcardiovascular risk factorcell typecirculatory systemcytokinedriving forcehost responsehuman diseasehydroxyaryl protein kinaseimmune system responseimmunoresponseinfection riskinhibition of autophagylipid mediatormembrane structurenew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwayplaques in atherosclerosispreventpreventingreceptorresolutionsretrograde transportscRNA sequencingscRNA-seqselective expressionselectively expressedsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesortilintissue repairtraffickingtranscriptome sequencingtranscriptomic sequencingtyrosyl protein kinase

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Project Summary/Abstract
Atherosclerotic cardiovascular disease (CVD), a chronic lipoprotein-driven inflammatory disorder, is the leading
cause of death worldwide. Conventional lipid-lowering therapies only modestly lower cardiovascular risk in the
population due to β€œresidual risk,” thought to be caused by excessive inflammation. Emerging evidence…

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EHD1-mediated Inflammation and Resolution in Atherosclerosis β€” ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | UNITED STATES | | Dev Procure