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Efficient IBD mapping for Alzheimer's Disease and related brain imaging phenotypes

Organization UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTONLocation HOUSTON, UNITED STATESPosted 30 Sept 2024Deadline 31 Dec 2025 ⚠️
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAD dementiaAccelerationAlgorithmic AnalysesAlgorithmic AnalysisAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's diagnosisAlzheimer's disease diagnosisAlzheimers DementiaAnalyses of AlgorithmsAnalysis of AlgorithmsBrain MappingBrain imagingCausalityCell Communication and SignalingCell SignalingClinicalCodeCoding SystemComplexComputational algorithmComputing MethodologiesDataDiseaseDisorderDrugsEtiologyGWA studyGWASGeneticGenetic ResearchGenetic predisposing factorGenomic SegmentGenotypeHaplotypesHeritabilityHistoryIBD analysisIBD inferenceImageImaging technologyIndividualIntracellular Communication and SignalingInvestigatorsJointsMapsMedicationMeta-AnalysisMethodsParticipantPharmaceutical PreparationsPhenotypePopulationPopulation HeterogeneityPrimary Senile Degenerative DementiaRecording of previous eventsResearchResearch PersonnelResearchersRisk-associated variantRunningSample SizeSamplingSignal TransductionSignal Transduction SystemsSignalingStatistical MethodsTestingbiobankbiological signal transductionbiorepositorybrain MR imagingbrain MRIbrain magnetic resonance imagingbrain visualizationcausal allelecausal genecausal mutationcausal variantcausationcausative mutationcausative variantcerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcomputational frameworkcomputational methodologycomputational methodscomputer algorithmcomputer based methodcomputer frameworkcomputer methodscomputing methoddata resourcedisease causationdiverse populationsdrug/agentempowermentendophenotypeflexibilityflexiblegenetic architecturegenetic associationgenetic informationgenetic risk factorgenome annotationgenome scalegenome segmentgenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic regionheterogeneous populationhistorieshuman diseaseidentical by descentidentity by descentimagingimprovedinherited factorinsightlarge scale datalarge scale data setslarge scale datasetsnovelpopulation diversityprimary degenerative dementiaprototypequantitative imagingrisk allelerisk generisk genotyperisk locirisk locusrisk variantsenile dementia of the Alzheimer typestatistic methodsthree dimensionaltooltraitwhole genome association analysiswhole genome association study

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PROJECT SUMMARY/ABSTRACT
Alzheimer’s Disease (AD) is a highly heritable complex human disease, but only a limited number of its genetic
risk factors have been identified. In this project, we propose to leverage identical-by-descent (IBD) segments,
which are expected to better tag haplotype effects and provide complementary genetic information to…

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