grant
Effects of Ventral Tegmental Area Dopamine Neurons GABA-B Receptor Deletion on Cue-Evoked Relapse and Aversion-Resistant Drinking
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 28 Aug 2024Deadline 27 Aug 2028
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAblationAbsolute ethanolAbstinenceAddressAgonistAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAminalonAminaloneAnteriorBaclofenBaclofen ReceptorsBehaviorBehavioralBilateralCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCannulasCas nuclease technologyChlorophenyl GABAClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCommon Rat StrainsComputer AnalysisControl GroupsCue-induced relapseCuesDA NeuronDataDevelopmentDopamineDopamine neuronDoseETOHEtOH drinkingEtOH useEthanolEthyl AlcoholExtinctionGABAGABA-B ReceptorGenesGoalsGrain AlcoholGuide RNAHistologicHistologicallyHydroxytyramineImaging ProceduresImaging TechnicsImaging TechniquesImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImplantInfusionInfusion proceduresInjectionsIntakeInvestigatorsLearningLong-Evans RatsMentorsMethodsMethylcarbinolMicroinjectionsModelingMolecular TargetMotivationMuscle relaxantsNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesOperative ProceduresOperative Surgical ProceduresPCP-GABAPatientsPopulationProbabilityProceduresPropertyQuinineRatRats MammalsRattusReceptor ActivationReceptor ProteinRelapseResearchResearch PersonnelResearchersResistanceRewardsRisk FactorsRodentRodent ModelRodentiaRodents MammalsRoleRunningSelf AdministeredSelf AdministrationSiteSourceSpecific qualifier valueSpecifiedStimulantSurgicalSurgical InterventionsSurgical ProcedureSystemTestingTrainingVentral Tegmental AreaViralViral VectorVisualizationWithdrawal SymptomWorkaddictionaddictive disorderalcohol behavioralcohol cuealcohol induced behavioralcohol ingestionalcohol intakealcohol product usealcohol relapsealcohol related behavioralcohol related cuealcohol seekingalcohol seeking behavioralcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakebehavior influencebehavioral influencecomputational analysescomputational analysiscomputer analysescue reactivitydevelopmentaldopaminergic neurondrinkingdrinking behaviordriving behaviorethanol behaviorethanol consumptionethanol cueethanol drinkingethanol induced behaviorethanol ingestionethanol intakeethanol product useethanol relapseethanol related behaviorethanol seekingethanol useethanol use disorderethanol-seeking behaviorexperimentexperimental researchexperimental studyexperimentsgRNAgamma-Aminobutyric Acidgene manipulationgenetic manipulationgenetically manipulategenetically perturbhabituationinfusionsinsightlong-term abstinenceneural mechanismneuromechanismneuronalreceptorresistantskillssocial rolesurgeryventral tegmentumγ-Aminobutyric Acid
Description preview
RESEARCH SUMMARY
Alcohol use disorder (AUD) is characterized by the inability to control or stop the use of alcohol, even in the
face of negative consequences or after long-term abstinence. Thus, it is important to understand the risk
factors that contribute to this loss of control such as environmental cues that can contribute to an increase in…
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