grant
Effects of maternal exercise on fetal akinesia-impaired bone and joint development
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 12 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAmniotic FluidAmyoplasia CongenitaAqua AmniiArthrogryposisBioreactorsBody TissuesBone DevelopmentBone FormationCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell SignalingCellsCellular MechanotransductionCongenital ArthromyodysplasiaConnective TissueCoxaDNA mutationDataDefectDevelopmentDevelopment and ResearchDysplasiaEireEmbryoEmbryonicExerciseExercise PhysiologyExhibitsExtremitiesFetal ActivityFetal MovementFetal SkeletonGDF5GDF5 geneGene TranscriptionGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsGrowth Differentiation Factor 5 GeneGuerin-Stern SyndromeHipHip region structureHumanImageImpairmentInternationalInterventionIntracellular Communication and SignalingIrelandIrish Free StateJointsKITLGKITLG geneKL-1Kit Ligand GeneKitlKnock-outKnockoutLigamentsLimb DevelopmentLimb structureLimbsLiquor AmniiMechanical Signal TransductionMechanical StimulationMechanosensory TransductionMediatingMeniscusMeniscus structure of jointMiceMice MammalsModelingModern ManMolecularMorphogenesisMovementMurineMusMuscle Cell ContractionMuscle ContractionMuscle DevelopmentMuscular ContractionMuscular DevelopmentMutationMyodystrophia Fetalis DeformansNon-TrunkOsteoblastsOsteogenesisOtto syndromePatientsPerinatal MortalitiesPerinatal lethalityPerinatal mortality demographicsPhenotypePopulationPositionPositioning AttributeR & DR&DRNA ExpressionRocher-Sheldon syndromeRoleRossi syndromeRunningSignal TransductionSignal Transduction SystemsSignalingSkeletal DevelopmentSkeletal MuscleTechniquesTendon structureTendonsTestingTherapeuticTherapeutic InterventionTissuesTranscriptionTranscriptional ControlTranscriptional RegulationVoluntary Musclearthrogryposis multiplex congenitabiological signal transductionbody movementbonebone tissue formationcell typecongenital arthromyodysplastic syndromecongenital contractures of extremitiesdevelopmentaldyscrasiafetalgenome mutationimagingin vivoinnovateinnovationinnovativeinsightintervention therapymechanical cuemechanical forcemechanical loadmechanical signalmechanosensingmechanotransductionmicrobioreactormorphogenetic processmorphometrymultiple congenital contracturesmuscle progenitormuscle progenitor cellmuscle stem cellmyodysplasia fibrosa multiplexmyodysplasia foetalis deformansmyodystrophia foetalis deformansneuro-arthromyodysplasianew approachesnovel approachesnovel strategiesnovel strategyosteoblast progenitorosteoblast stem cellosteogenic progenitorosteogenic stem cellosteoprogenitorosteoprogenitor cellperinatal deathspharmacologicprogenitorprogramsresearch and developmentresponsescRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletalskeletal diseaseskeletal disorderskeletal progenitorskeletal progenitor cellskeletal stem cellsocial rolethree dimensionaltissue progenitortissue specific progenitor cellstissue specific stem cellstissue stem cells
Description preview
Abstract
Mechanical forces exerted by fetal movement during development influence skeletal morphogenesis. Thus,
fetal akinesia (insufficient movement), caused by low amniotic fluid volume, breech position or impaired muscle
development, can cause skeletal disorders such as hip dysplasia, arthrogryposis, and impaired bone
development. We found…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click