grant
Effects of genetic polymorphism in MHC, KIR, and related loci on human disease
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025A33AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAffectAffinityAllelesAllelomorphsAmino AcidsAsian groupAsian individualAsian peopleAsian populationAsiansAssayAutoimmune DiseasesBindingBioassayBiologicalBiological AssayBiological FunctionBiological ProcessBlackBlack raceBlood leukocyteBurkitt HerpesvirusBurkitt Lymphoma VirusCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD94CD94 AntigenCMVCMV pp65 antigenCancersCell BodyCell LineCell surfaceCellLineCellsCharacteristicsClass I AntigensClass I GenesClass I Major Histocompatibility AntigensCommunicable DiseasesComplexComplex Class 1CytomegalovirusCytomegalovirus UL83 proteinCytomegalovirus pp65 proteinCytomegalovirus ppUL83 proteinCytotoxic cellDataData BasesData SetDatabasesDependenceDiseaseDisease OutcomeDisorderEB virusEBVEBV InfectionsEndosomesEpstein Barr VirusEpstein-Barr Virus InfectionsEpstein-Barr viral infectionsFutureGPA33GPA33 geneGene FrequencyGenesGeneticGenetic PolymorphismGenotypeGoalsHCMVHHV-4HHV4HIVHIV-1HIV-IHIV1HL-A AntigensHLA AntigensHLA testingHLA typingHaplotypesHerpes SimplexHerpes Simplex InfectionsHerpes ZosterHerpes infectionHerpes simplex diseaseHerpes zoster diseaseHerpesviridaeHerpesviridae InfectionsHerpesviridae diseaseHerpesvirus InfectionsHerpesvirus hominis diseaseHerpesvirusesHistocompatibility Antigens Class IHodgkin DiseaseHodgkin DisorderHodgkin lymphomaHodgkin'sHodgkin's LymphomaHodgkin's diseaseHodgkins lymphomaHumanHuman CharacteristicsHuman Herpesvirus 4Human Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman Leukocyte AntigensHuman NatureHuman immunodeficiency virus 1HydrophobicityImmuneImmune GlobulinsImmune Response GenesImmune responseImmunesImmunogeneticsImmunoglobulinsImmunologic ReceptorsImmunological ReceptorsImmunotherapeutic agentIn VitroIncidenceIndividualInfectionInfectious DiseasesInfectious DisorderInfectious Mononucleosis VirusInnate Immune ResponseIntegral Membrane ProteinInterruptionIntrinsic Membrane ProteinIr GeneK CellsK lymphocyteKLRD1KLRD1 ProteinKLRD1 geneKP43Killer Cell Lectin-Like Receptor Subfamily D, Member 1Killer Cell Lectin-Like Receptor Subfamily D, Member 1 GeneKiller Cell Lectin-Like Receptor Subfamily D, Member 1 Isoforms 1, 2Killer Cell Lectin-Like Receptor Subfamily D, Member 1 ProteinKiller CellsKnock-outKnockoutKnowledgeKp43 antigenLAV-HTLV-IIILeukocyte AntigensLeukocytesLeukocytes Reticuloendothelial SystemLifeLigandsLymphadenopathy-Associated VirusMHC Class IMHC Class I GenesMHC Class I MoleculeMHC Class I ProteinMHC class I antigenMajor Histocompatibility Complex Class 1Malignant LymphogranulomaMalignant NeoplasmsMalignant TumorMarrow leukocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMembraneMessenger RNAModern ManMolecularMolecular InteractionMolecular Modeling Nucleic Acid BiochemistryMolecular Modeling Protein/Amino Acid BiochemistryMolecular ModelsNK Cell ReceptorNK CellsNK receptorNasopharyngeal CarcinomaNasopharynx CarcinomaNatural HistoryNatural Killer CellsNatural Killer Cells Antigen CD94OutcomePeptide FragmentsPeptide Signal SequencesPeptidesPhysiologic pulsePopulationPredispositionProcessPropertyProtein FragmentProteinsPulseReceptor ProteinReceptosomesReporterReportingResearch ResourcesResistanceResourcesRiskSalivary Gland VirusesSclerosisShinglesSignal PathwaySignal PeptideSignal SequencesSiteStrains Cell LinesSusceptibilityT cell responseT-Cell ActivationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTestingTransmembrane ProteinTransmembrane Protein GeneTransplantationVariantVariationViralViral BurdenViral LoadViral Load resultVirusVirus-HIVWhite Blood CellsWhite CellZonaZosteractivate T cellsallelic frequencyaminoacidantigen bindingantigen boundautoimmune conditionautoimmune disorderautoimmunity diseasebiobankbiologicbiorepositorycell transductioncellular transductioncohortcultured cell linecytomegalovirus groupcytomegalovirus matrix protein 65kDacytomegalovirus phosphoprotein 65cytomegalovirus pp65 matrix proteindata basegenetic associationherpes simplex virus 1 infectionherpes simplex virus infectionherpes virusherpes zonahost responsehuman diseasehuman leukocyte antigen testinghuman leukocyte antigen typingimmune drugsimmune receptorimmune system responseimmune-based therapeuticsimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentinterestlatent infectionmRNAmalignancymembrane structuremolecular modelingneoplasm/cancernovelpeptide Ipolymorphismpredictive toolsprotective alleleprotective effectprotective variantprotein signal sequencereceptorresistantresponseseropositivesouth east asiansoutheast Asianthermolabilitythermostabilitythymus derived lymphocytetooltransduced cellstransplantvaccine responsevaccine responsivenessvaccine-induced responsewhite blood cellwhite blood corpuscle
Description preview
HLA-A02:01 is the most common allele in White and Black US populations, present at allelic frequencies 28% and 12%, respectively. This allele has been reported to associate with protection in human herpesvirus infection. We have conducted analysis in the UK Biobank dataset across various herpesvirus-associated diseases, and observed multiple…
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