grant
Effects of early sensory loss on the developing auditory thalamocortical circuit
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 11 May 2026Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20262-photon21+ years oldAdultAdult HumanAnatomic SitesAnatomic structuresAnatomyAreaAuditoryAuditory CortexAuditory areaBrainBrain Nervous SystemCalciumCell Communication and SignalingCell SignalingCochlear ImplantationCochlear Prosthesis ImplantationCochlear implant procedureCompensationDNA TherapyDWI (diffusion weighted imaging)DWI-MRIDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiseaseDisorderEar CanalEncephalonEnsureExternal Acoustic MeatusExternal auditory canalFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence In Situ HybridizationFluorescent in Situ HybridizationFoundationsGene ExpressionGene ModifiedGene Transfer ClinicalGenerationsGenetic InterventionGoalsHearingHearing LossHypoacusesHypoacusisImageImaging ProceduresImaging TechnicsImaging TechniquesIn Situ HybridizationIndividualInterventionIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceLabelLeadLifeLightMapsMasksMethodologyNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNull MouseOTOF geneOTOF proteinOutcomePathway interactionsPatternPb elementPeripheralPhotoradiationProcessReactionResearchResolutionRoleSensorineural DeafnessSensorineural Hearing LossSensorySensory Hearing LossShapesSignal TransductionSignal Transduction SystemsSignalingStructureTestingThalamic NucleiThalamic structureThalamusTherapeuticTherapeutic InterventionTransgenic MiceTransmissionTreatment outcomeVirusadulthoodauditory processingaxon growthaxonal growthbiological signal transductioncalcium indicatorcongenital deafnesscongenitally deafcritical perioddMRIdeafdeafeneddeafnessdevelopmentaldiffusion tensor imagingdysfunctional hearingeffective therapyeffective treatmentexperiencefluorophoregene modificationgene repair therapygene therapygene-based therapygenetic therapygenetically modifiedgenomic therapyhearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthearing restorationheavy metal Pbheavy metal leadhuman imagingimagingimprovedin situ Hybridization Geneticsin situ Hybridization Staining Methodinnervationinnovateinnovationinnovativeinsightintervention therapymicroscope imagingmicroscopic imagingmicroscopy imagingmouse modelmurine modelnerve supplyneurobiological mechanismneuronaloptimal therapiesoptimal treatmentsotoferlinpathwaypost-natal developmentpostnatal developmentpreservationprofound hearing lossresolutionsrestore hearingsensorineural hearing impairmentsocial rolesoundsynaptic pruningthalamicthalamic radiationthalamocortical tracttherapy optimizationtransmission processtreatment optimizationtwo-photon
Description preview
Project Summary
The auditory cortex is the central hub for sound processing, with the thalamus serving as the “gateway”
for conveying auditory information to the auditory cortex. Proper maturation of the thalamocortical circuit depends
on sensory experience. In cases of congenital deafness, the absence of auditory input to the thalamus leads to…
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