grant
Effects of Early-life Cannabinoid Exposure on Prefrontal Circuitry and Cognitive Behavior across Development
NIHUS FederalResearch GrantFY20260-11 years old12-20 years old2-photon21+ years old9-ene-TetrahydrocannabinolAddressAdolescenceAdultAdult HumanAffectAffective DisordersBehaviorBehavior assessmentBehavioralBrainBrain Nervous SystemCB1CB1 ReceptorCB1RCCKCNR1 geneCalciumCannabidiolCannabinoid Receptor CB1CannabinoidsCannabisCell BodyCellsChildChild YouthChildren (0-21)CholecystokininClinicalClinical DataClinical ResearchClinical StudyCognitiveCognitive deficitsConnector NeuronConsumptionD9-tetrahydrocannabinolDelta-9-TetrahydrocannabinolDevelopmentDevelopmental ProcessECB signalingEmotionalEncephalonEndocannabinoidsEndogenous CannabinoidsEquilibriumExposure toGestationGoalsGuidelinesHeadImageImaging ProceduresImaging TechnicsImaging TechniquesIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronInterventionLactationLegalLifeLinkLong-Term EffectsMeasuresMedialMediatingMedicalMiceMice MammalsMood DisordersMothersMurineMusNatural RemedyNeonatalNerve CellsNerve UnitNeural CellNeural DevelopmentNeurocyteNeuronsOutcomePancreozyminPatternPerceptionPerformancePerinatalPeripartumPopulationPostpartum PeriodPreclinical dataPrefrontal CortexPregnancyPregnant WomenPyramidal neuronRabies mappingRabies trans synaptic tracingRabies virus mediated mappingReceptor ActivationRiskRisk AssessmentRoleSynapsesSynapticTHC co-useTHC exposureTHC useTestingTetrahydrocannabinolTetrahydrocannabinol co-useTetrahydrocannabinol useUropancreozyminadolescence (12-20)adulthoodanxiety-related behaviorbalancebalance functionbehavior outcomebehavioral assessmentbehavioral outcomecalcium indicatorcannabinoid receptorcannabinoid receptor 1cannabinoid receptor type 1cannabinoid type 1cannabis usecell typecognitive defectscognitive taskcohortdelta(1)-THCdelta(1)-Tetrahydrocannabinoldelta(9)-THCdelta(9)-TetrahydrocannabinoldevelopmentaleCB systemearly adulthoodearly life exposureemerging adultendocannabinoid signalingendocannabinoid systemendogenous cannabinoid systemexogenous cannabinoidexpectant motherexpectant womenexpecting motherexpecting womenhippocampal pyramidal neuronillicit drug useimagingin vivoindividuals who are pregnantkidslactatinglactationallater in lifelater lifemarijuana useneuralneural correlateneural mechanismneurodevelopmentneuromechanismneuronalnovelnursing motherspatch clamppeople who are pregnantpharmacologicpost-partumpostnatalpre-clinical studypreclinical findingspreclinical informationpreclinical studypregnant femalespregnant motherspregnant peoplepregnant populationsprenatalpuprabies based mappingrabies based retrograde mappingrabies circuit tracingrabies mediated retrograde monosynaptic tracingrabies retrograde tracingrabies tracerrabies tracingrabies viral tracingrabies virus mediated circuit mappingrabies virus monosynaptic circuit tracingrabies virus monosynaptic tracingrabies virus neurotracerrabies virus retrograde tracingrabies virus tracingreceptor expressionsensorsocialsocial rolespatial and temporalspatial temporalspatiotemporalsynapsetetrahydrocannabinol exposurethose who are pregnanttracing with rabiestranslational impacttwo-photonunbornwomen who are pregnantyoungsterΔ(1)-THCΔ(1)-tetrahydrocannabinolΔ(9)-THCΔ(9)-tetrahydrocannabinolΔ-9-tetrahydrocannabinolΔ9-tetrahydrocannabinol
Description preview
PROJECT SUMMARY
Cannabis consumption during pregnancy and lactation has reached 7-15% in pregnant women and nursing
mothers in recent years, and will likely rise due to widespread legalization. Increased availability of cannabis has
led to the public perception that it is a safe natural remedy for pregnancy-related ailments and postpartum mood…
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