grant
Effects of a non-nutritive sweetener reduction intervention in pregnancy and lactation on maternal and infant outcomes (the SWEETPEA trial)
Organization GEORGE WASHINGTON UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2029
NIHUS FederalResearch GrantFY202621+ years oldAdherenceAdultAdult HumanAffectAge MonthsAirAutomobile DrivingBMIBMI percentileBMI z-scoreBeveragesBlood GlucoseBlood SugarBody CompositionBody fatBody mass indexBreast MilkBreastmilkCardiometabolic DiseaseCardiometabolic DisorderChildhoodChronicCohort StudiesConsultationsConsumptionControl GroupsCounselingDataDevelopmentDietitianDiseaseDisorderEthicsExclusive BreastfeedingExposure toFatsFatty acid glycerol estersFecesFoodFunctional MetagenomicsFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGeneralized GrowthGestationGestational DiabetesGestational Diabetes MellitusGlucose IntoleranceGrowthGuidelinesHealthHomeHourHumanHuman CharacteristicsHuman MilkHuman Mother's MilkHuman NatureHypoglycemiaInfantInfant HealthInflammationInflammatoryIntakeInterventionLactationLeannessLifeMammary Gland MilkMaternal HealthMaternal NutritionMaternal dietMeasuresMetabolicMetagenomicsMiceMice MammalsMicrobeModern ManMother's MilkMothersMurineMusOGTTObesityObservational StudyOral Glucose Tolerance TestOutcomePathway interactionsPhysiologicPhysiologicalPlethysmographyPostpartum PeriodPregnancyPregnancy-Induced DiabetesPregnant WomenProspective, cohort studyQuetelet indexRandomizedRandomized, Controlled TrialsRecommendationReportingResearchRisk FactorsRodentRodent ModelRodentiaRodents MammalsSafetyShapesSolidSweetenersSweetening AgentsThinnessTissue GrowthToxicologyTransmissionUnited StatesUrineUterusWeightWomanadiposityadulthoodblood glucose regulationcardiometabolic riskcohort research studycohort surveyconsultationcorpulencedevelopmentaldiabetes riskdietarydigestive tract microbiomedisease riskdisorder riskdosagedrivingearly life exposureenteric microbial communityenteric microbiomeenteric microbiotaethicalexpectant motherexpectant womenexpecting motherexpecting womenexposed in uterofetalfetal exposuregastrointestinal microbial floragastrointestinal microbiomeglucose controlglucose homeostasisglucose regulationglucose tolerancegut communitygut dysbiosisgut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiomegut microbiome of infantgut microbiotagut microbioticgut microfloragut-associated microbiomehomeshypoglycemichypoglycemic episodesimprovedin uteroin utero exposureindividuals who are pregnantinfant adiposityinfant gut microbiomeinfant obesityinfant outcomeinfantile obesityinsulin sensitivityintergenerationalintestinal biomeintestinal floraintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microfloraintra-uterine environmental exposureintrauterine environmental exposurelactatinglactationalmaternal milkmaternal nutrition during pregnancymaternal outcomemetabolism measurementmetabolomemetabolomicsmetabonomemetabonomicsmother nutritionmother outcomeneonate gut microbiomenewborn gut microbiomeobesity among infantsobesity in infantsobservational research studyobservational surveyoffspringoffspring obesityontogenypathwaypediatricpeople who are pregnantpost-partumpostnatalpregnancy diabetespregnant femalespregnant motherspregnant peoplepregnant populationsprenatalprenatal exposureprenatally exposedrandomisationrandomizationrandomized control trialrandomly assignedrecruitstoolthose who are pregnanttransmission processunbornweightswombwomen who are pregnant
Description preview
ABSTRACT
Increasing evidence demonstrates that suboptimal conditions in the womb, including poor maternal nutrition,
contributes to obesity and cardiometabolic disease risk. One potential contributor to poor maternal nutrition is
chronic consumption of non-nutritive sweeteners (NNS). Studies indicate that approximately 30% of pregnant
women and…
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