grant
Early mid-life environmental toxicant exposures and AD/ADRD risk in CARDIA
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 30 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD preventionAD related dementiaADRDAI systemActive Follow-upAddressAffectAfrican AmericanAfro AmericanAfroamericanAgeAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease preventionAlzheimer preventionAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimers DementiaAmericanArtificial IntelligenceAssayBenzochlorylBioassayBiologicalBiological AssayBiological FunctionBiological MarkersBiological ProcessBlackBlack PopulationsBlack groupBlack individualBlack peopleBlack raceBlacksBloodBlood PlasmaBlood Reticuloendothelial SystemBrainBrain Nervous SystemCadmiumCd elementCerebrovascular CirculationChemicalsChlorinated HydrocarbonsCitiesClinicalCognitionCognitive DiscriminationCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCohort StudiesCommunitiesComputer ReasoningConcurrent StudiesCoronary Artery Risk Development in Young AdultsCoronary Artery Risk Development in Young Adults StudyCoupledDNA MethylationDataData AnalysesData AnalysisDevelopmentDiscriminationDiseaseDisorderDisturbance in cognitionEcological impactEducationEducational aspectsEncephalonEnrollmentEnvironmental ExposureEnvironmental FactorEnvironmental ImpactEnvironmental Risk FactorEnvironmental ToxinEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toFundingFutureGeneticGenomicsHeavy MetalsHigh PrevalenceImpaired cognitionImpoverishedJointsLaboratoriesLeadLinkLong-Term EffectsMR ImagingMR TomographyMRIMRIsMachine IntelligenceMagnetic Resonance ImagingMapsMeasuresMediatingMediationMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMendelian randomizationMetalsModificationNHLBINIH RFANMR ImagingNMR TomographyNational Heart, Lung, and Blood InstituteNegotiatingNegotiationNerve DegenerationNeuron DegenerationNuclear Magnetic Resonance ImagingOrganochlorine CompoundsOrganochlorinesOrganophosphatesOxidative StressPCBsParticipantPathogenesisPathway interactionsPatternPb elementPersonsPesticidesPlasmaPlasma SerumPolychlorinated BiphenylsPolychlorobiphenyl CompoundsPovertyPrevalencePrimary Senile Degenerative DementiaProcessPropertyRNA SeqRNA sequencingRNAseqRequest for ApplicationsResearchReticuloendothelial System, Serum, PlasmaRiskRoleSamplingStructureSymptomsTOPMedTechniquesThickThicknessTimeToxic Environmental AgentsToxic Environmental SubstancesToxicant exposureTrans-Omics for Precision MedicineUrineZeugmatographyactive followupadult youthagesalzheimer riskbi-racialbio-markersbiologicbiologic markerbiomarkerbiracialblood flow in brainbrain MR imagingbrain MRIbrain blood circulationbrain blood flowbrain magnetic resonance imagingcerebral MR imagingcerebral MRIcerebral blood flowcerebral circulationcerebral magnetic resonance imagingcerebrocirculationcerebrovascular blood flowchemical associationchlorinated hydrocarbon pesticidechlorohydrocarboncognitive changecognitive dysfunctioncognitive functioncognitive losscohortdata interpretationdementia riskdevelopmentaldichlorodiphenyltrichloroethanedifferences due to racedifferences in racediffers by racediffers in racedisparities in racedisparity due to racedisparity in healthenrollentire genomeenvironmental chemicalenvironmental riskenvironmental toxicantepigenetic biomarkerepigenetic markerepigeneticallyepigenomicsexposomeexposomicsfollow upfollow-upfollowed upfollowupfull genomegenome sequencinghealth disparityheavy metal Pbheavy metal leadindividualized preventioninequality due to raceinequity due to raceinsightlater in lifelater lifemachine learning based methodmachine learning methodmachine learning methodologiesmid lifemid-lifemiddle agemiddle agedmidlifemultiomicsmultiple omicsneural degenerationneural imagingneural inflammationneuro-imagingneurodegenerationneurodegenerativeneuroimagingneuroinflammationneuroinflammatoryneurological degenerationneurological imagingneuronal degenerationneurotoxicnovelolder adultolder adulthoodorganochlorine pesticidep',p'-DDTpanomicspathwaypersistent organic pollutantspersonalized preventionpolybrominated biphenyl etherpolybrominated diphenyl etherpolychlorobiphenylpre-clinicalprecision preventionpreclinicalprimary degenerative dementiaprogramsrace based differencesrace based disparityrace based inequalityrace based inequityrace differencesrace disparityrace related differencesrace related disparityrace related inequalityrace related inequityracial differenceracial disparityracial inequalityracial inequityracially differentracially unequalrecruitrisk factor for dementiarisk for dementiascreeningscreeningssenile dementia of the Alzheimer typesexsocial health determinantssocial rolesubstantia albasystemic inflammationsystemic inflammatory responsetoxic exposuretoxicanttranscriptome sequencingtranscriptomic sequencingtranscriptomicswhite matterwhole genomeyoung adultyoung adult ageyoung adulthoodyounger age
Description preview
Project summary
Alzheimer's Disease (AD) and AD-related dementias (ADRD) affect more than 6 million Americans and 55 million
people worldwide. Environmental toxicant exposures from younger age have not been systematically
investigated for their roles in AD/ADRD risk despite limited suggestive evidence for organochlorine pesticide
DDT,…
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