grant
Dysregulation of calcium signaling in the initiation of fatty liver disease
Organization RUTGERS BIOMEDICAL AND HEALTH SCIENCESLocation Newark, UNITED STATESPosted 1 Aug 2024Deadline 31 May 2028
NIHUS FederalResearch GrantFY20251,2-diacylglycerolAcetyl Coenzyme A CarboxylaseAcetyl-CoA CarboxylaseAddressAdipose tissueAdult-Onset Diabetes MellitusAffectAntidiabetic HormoneAttenuatedAutomobile DrivingCalciumCalcium Ion SignalingCalcium Phospholipid-Dependent Protein KinaseCalcium SignalingCalcium-Activated Phospholipid-Dependent KinaseCatecholaminesCell Communication and SignalingCell RespirationCell SignalingCell surfaceCellular RespirationChiro-InositolDataDevelopmentDiabetes MellitusDiacylglycerolsDietDiglyceridesDysfunctionEndocrine Gland SecretionEnzyme GeneEnzymesEquilibriumFatsFatty LiverFatty TissueFatty acid glycerol estersFeedbackFunctional disorderG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGenerationsGlucagonGluconeogenesisGlukagonHG-FactorHepaticHepatic CellsHepatic DisorderHepatic Parenchymal CellHepatic lobuleHepatocyteHigh Fat DietHormonesHumulin RHyperglycemic-Glycogenolytic FactorImpairmentIndividualInitiation FactorsInositolInsulinInsulin ResistanceIntermediary MetabolismIntracellular Communication and SignalingIntracellular Second MessengerInvestigatorsIsoformsKetosis-Resistant Diabetes MellitusLecithinase CLesionLevarterenolLevonorepinephrineLinkLipaseLipidsLipolysisLiverLiver CellsLiver SteatosisLiver diseasesLobularLobuleMaturity-Onset Diabetes MellitusMediatingMesoinositolMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaMolecularMolecular TargetMurineMusNAFLDNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNoradrenalineNorepinephrineNovolin RObesity EpidemicPathogenesisPathway interactionsPeptide Initiation FactorsPerfusionPhasePhosphatesPhospholipase CPhospholipid-Sensitive Calcium-Dependent Protein KinasePhysiopathologyPlayPrevalencePreventionProtein IsoformsProtein Kinase CRegular InsulinRegulationResearch PersonnelResearchersResistanceRoleSecond Messenger SystemsSecond MessengersSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSlow-Onset Diabetes MellitusStable Diabetes MellitusStaining methodStainsStratificationSympathinsT2 DMT2DT2DMTechniquesTestingTherapeutic HormoneTranslation Initiation FactorTranslational Initiation FactorTriacylglycerolTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriglyceridesTriolean HydrolaseType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUpregulationWorkadipogenesisadiposeadult onset diabetesaerobic metabolismaerobic respirationattenuateattenuatesbalancebalance functionbiological signal transductioncarbohydrate metabolismco-morbidco-morbiditycomorbiditydevelopmentaldiabetesdiacylglyceroldiet-associated obesitydiet-induced obesitydiet-related obesitydietsdiglyceridedrivingeuglycemiafat metabolismfatty acid oxidationfatty liver diseasefeedingglucose biosynthesisglucose outputglycogenolysishepatic body systemhepatic diseasehepatic metabolismhepatic organ systemhepatic steatosishepatopathyhepatosteatosishormonal regulationhormone regulationin vivoinorganic phosphateinsulin resistantinsulin toleranceintra-vital imagingintravital imagingketosis resistant diabetesknock-downknockdownlipid biosynthesislipid metabolismlipogenesislipophosphodiesterase Iliver developmentliver disorderliver metabolismmaturity onset diabetesmitochondrialmitochondrial metabolismmouse modelmurine modelnon-alcohol fatty liver diseasenon-alcoholic fatty liver diseasenon-alcoholic liver diseasenonalcoholic fatty liver diseasenoveloxidationoxidative metabolismpathophysiologypathwayphosphatidylcholine cholinephosphohydrolaseresistantresponsesegregationsignal transduction second messengerssocial rolesynergismtherapeutic targettooltributyrasetype 2 DMtype II DMtype two diabetesuptakewhite adipose tissueyellow adipose tissue
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ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is linked to insulin resistance, type 2 diabetes mellitus (T2DM) and
several other major comorbidities. Hepatic carbohydrate and lipid metabolism is maintained by the balance
between anabolic hormones, primarily insulin, and catabolic hormones including glucagon and catecholamines.
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