grant
Dysregulated cholesterol metabolism in Alzheimer's Disease astrocytes: Investigating contributions to neuronal dysfunction
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jul 2023Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026AD brainAD dementiaAD pathologyAD patientsAD therapyAD treatmentAddressAdoptionAffectAgeAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer disease treatmentAlzheimer sclerosisAlzheimer syndromeAlzheimer treatmentAlzheimer'sAlzheimer's DiseaseAlzheimer's brainAlzheimer's disease brainAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease therapeuticAlzheimer's disease therapyAlzheimer's pathologyAlzheimer's patientAlzheimer's therapeuticAlzheimer's therapyAlzheimers DementiaAmentiaAmericanApolipoproteinsAssayAstrocytesAstrocytusAstrogliaAutoregulationBehavioralBioassayBioinformaticsBiologicalBiological AssayBiologyBlood VesselsBrainBrain Nervous SystemCause of DeathCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell-Extracellular MatrixCell-to-Cell InteractionCellsCholesterolCholesterol HomeostasisCommunicationCytokine Signal TransductionCytokine SignalingDataData BasesData SetDatabasesDegenerative Neurologic DisordersDementiaDevelopmentDiagnosisDiseaseDisorderDoctor of PhilosophyDysfunctionECMEncephalonEnvironmentExhibitsExperimental DesignsExposure toExtracellular MatrixFunctional disorderGenerationsGenesGliaGlial CellsGoalsHealthHomeostasisImpairmentIn VitroIndividualInflammationInflammatoryIntermediary MetabolismIntracellular Communication and SignalingInvestigatorsKolliker's reticulumLaboratoriesLifeLipid TraffickingLipidsLipoproteinsMeasuresMembraneMetabolicMetabolic PathwayMetabolic ProcessesMetabolismMultiomic DataNerve CellsNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural TransmissionNeural degenerative DisordersNeuritesNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeuron DegenerationNeuronal DysfunctionNeuronsNeurosciencesNon-neuronal cellNonneuronal cellOutcomePathologyPathway interactionsPatientsPh.D.PhDPhasePhenotypePhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayPostdocPostdoctoral FellowPrimary Senile Degenerative DementiaPrincipal InvestigatorPropertyProteomeR-Series Research ProjectsR01 MechanismR01 ProgramRegulationResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRoleSignal TransductionSignal Transduction SystemsSignalingSignaling MoleculeSourceSynapsesSynapticSynaptic TransmissionSystemTechnical ExpertiseTechniquesTrainingTransgenic MiceTransgenic ModelUnited StatesViralWild Type Mouseage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage related neurodegenerationage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderagesaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderastrocytic gliabiologicbiological signal transductioncandidate identificationcareercell typecholesterol metabolismcompare to controlcomparison controldata basedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentaleffective therapyeffective treatmentexperimentexperimental researchexperimental studyexperimentsfat metabolismglobal gene expressionglobal healthglobal transcription profilehuman progenitorhuman stem cellsiPSiPSCiPSCsin vivoin vivo Modelinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellknock-downknockdownlipid metabolismlipid transportmembrane structuremetabolism measurementmetabolomicsmetabonomicsmouse modelmulti-electrode arraysmultielectrode arraysmultiomicsmultiple omic datamultiple omicsmurine modelnerve cell deathnerve cell lossnerve cementneural degenerationneural dysfunctionneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuron cell deathneuron cell lossneuron deathneuron lossneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal degenerationneuronal lossneurotoxicnoveloverexpressoverexpressionpanomicspathophysiologypathwaypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepatients with ADpost-docpost-doctoralpost-doctoral traineepost-doctoral trainingpostsynapticpresynapticpreventpreventingprimary degenerative dementiaprogenitor cell modelprogenitor modelresearch associatesresponsesenile dementia of the Alzheimer typeskillssocial rolestable isotopestem and progenitor cell modelstem cell based modelstem cell derived modelstem cell modelsynapsesynapse formationsynaptogenesistechnical skillstraffickingtranscriptometransgenic traituptakevascularwildtype mouse
Description preview
Project Summary
The absence of effective therapies to slow or prevent progression have made Alzheimer’s Disease (AD)
a global health crisis. Inflammation, neuronal dysfunction, and eventual neuronal loss are hallmarks of AD.
Cholesterol metabolism is also implicated in AD and other neurodegenerative diseases. For example,
accumulation of lipid…
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