grant
Dynorphin, a novel paracrine factor that regulates insulin secretion
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 17 Apr 2023Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAdult-Onset Diabetes MellitusAminalonAminaloneAntidiabetic HormoneB9 endocrine pancreasBeta CellBindingCell BodyCell CommunicationCell Communication and SignalingCell FunctionCell InteractionCell PhysiologyCell ProcessCell SignalingCell secretionCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCellular SecretionCellular injuryCommunicationCyclic SomatostatinD CellsD-GlucoseDataDelta CellDextroseDiabetes MellitusDiseaseDisorderDynorphinsEndocrine Gland SecretionEndocrine PancreasEpidemicExposure toFamilyFeedbackGABAGenesGeneticGlucagonGlucoseGlukagonGoalsGrowth Hormone Inhibiting FactorsGrowth Hormone-Inhibiting HormoneHG-FactorHigh Fat DietHormonalHormone secretionHormonesHumanHumulin RHyperglycemiaHyperglycemic-Glycogenolytic FactorImpairmentIn VitroIncubatedInsulinInsulin CellInsulin ResistanceInsulin Secreting CellIntracellular Communication and SignalingIslands of LangerhansIslet CellIslets of LangerhansKetosis-Resistant Diabetes MellitusKnowledgeLifeMaturity-Onset Diabetes MellitusMessenger RNAMiceMice MammalsModelingModern ManMolecular InteractionMurineMusNIDDMNesidioblastsNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin ROpiate AntagonistOpiate PeptidesOpiate ReceptorsOpiate receptor antagonistOpioid AntagonistOpioid PeptideOpioid ReceptorOpioid receptor antagonistOutcomePainPainfulPancreatic IsletsParacrine CommunicationParacrine SignalingPars endocrina pancreatisPathologicPhenotypePhysiologicPhysiologicalPhysiologyPublic HealthPublishingRegular InsulinRegulationResearchRoleSRIHSRIH-14Signal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSomatostatinSomatostatin CellsSomatostatin Secreting CellSomatostatin-14Somatotropin Release Inhibiting FactorsSomatotropin Release-Inhibiting HormoneStable Diabetes MellitusSubcellular ProcessSystemT2 DMT2DT2DMTestingTherapeuticTherapeutic HormoneType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesWorkaddictionaddictive disorderadult onset diabetesbiological adaptation to stressbiological signal transductionblood glucose regulationcell damagecell injurycellular damagedamage to cellsdesigndesigningdiabetesdiabetes managementdiabetes mellitus managementdiabetic managementdiabetogenicendogenous opiateendogenous opioidsexperimentexperimental researchexperimental studyexperimentsgamma-Aminobutyric Acidglucose controlglucose homeostasisglucose metabolismglucose regulationgrowth hormone release inhibiting factorhormonal secretionhyperglycemicimprovedin vivoinjury to cellsinnovateinnovationinnovativeinsulin granuleinsulin resistantinsulin secretioninsulin toleranceisletkappa opiatekappa opioidkappa opioid receptorsketosis resistant diabetesmRNAmaturity onset diabetesmouse modelmurine modelnew approachesnovelnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionparacrinepharmacologicprogramsreaction; crisisresponsesocial rolestress responsestress; reactiontherapeutic targettype 2 DMtype II DMtype two diabetesurocortinurocortin Iβ-cellβ-cellsβCellγ-Aminobutyric Acidκ opiateκ opioidκ opioid receptorsκ-ORκOR
Description preview
Dynorphin, a novel paracrine factor that regulates insulin secretion
The inability to maintain glucose homeostasis leads to diabetes, a life-threatening disease of epidemic
proportions. The adaptation of pancreatic islets to insulin resistance is a significant determinant of developing
type 2 diabetes (T2D). Within the pancreatic islet, the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click