grant
Dynamics of viral infection
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Antigen PresentationAntigensBiophysicsCell BodyCell Communication and SignalingCell SignalingCellsCognitive DiscriminationCoronaviridaeCoronavirusCross PresentationCytotoxic cellDefectDiscriminationFeedbackGoalsHumanImmuneImmune EvasionImmune responseImmunesImmunologyIndividualInfectionInnate Immune ResponseInterventionIntracellular Communication and SignalingK lymphocyteKineticsLife CycleLife Cycle StagesLigandsMeasurementMessenger RNAModelingModern ManMonitorNK CellsNatural Killer CellsNon-Polyadenylated RNAOrthocoronavirinaePathway interactionsProtein BiosynthesisRNARNA Gene ProductsRibonucleic AcidRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisSignal TransductionSignal Transduction SystemsSignalingT-Cell ActivationT-CellsT-LymphocyteViralViral DiseasesViral Gene ProductsViral Gene ProteinsViral GenomeViral PathogenesisViral ProteinsVirusVirus DiseasesVirus Replicationactivate T cellsbiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencescell typecorona virushost responseimmune evasiveimmune system responseimmunogenimmunoresponseinterestlife coursemRNAnew approachesnovel approachesnovel strategiesnovel strategypathogenpathwayprotein synthesissensorthymus derived lymphocyteviral RNAviral detectionviral infectionviral multiplicationviral replicationvirus RNAvirus detectionvirus genomevirus infectionvirus multiplicationvirus pathogenesisvirus proteinvirus-induced disease
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Our recent projects pivoted from immune responses to coronaviruses to the more fundamental aspects of host/pathogen interactions namely the tug-of-war between viral replication and innate immune response at the individual cell level. Cytosolic viral sensors (CyVSP) like PKR, RIG-I, and MDA5 initiate innate immune responses upon detecting viral…
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