grant
Dynamic interplay between genome organization and long noncoding RNAs in the regulation of gene expression
Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 6 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DArchitectureAutoregulationBase PairingBiologic ModelsBiological ModelsCell NucleusChromatinComplexDevelopmentDevelopmental GeneDiseaseDisorderDrosophilaDrosophila genusElementsEmbryoEmbryonicEngineering / ArchitectureEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFAST KinaseFAST geneFAST proteinFASTKFASTK GeneFLJ13079Fas-activated serine-threonine kinaseFosteringFunctional RNAFutureGene Action RegulationGene ActivationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGeneticGenetic TranscriptionGenomeGenomicsGoalsHomeostasisImageMeasuresMediatingMethodsModel SystemMolecularNoncoding RNANontranslated RNANucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNucleusOrganismPRC1PRC1 ProteinPhysiological HomeostasisPlayPolycomb Repressive Complex 1RNA ExpressionRegulationRegulatory RegionsResearchRoleTranscriptionTranscription ActivationTranscriptional ActivationTranscriptional ControlTranscriptional RegulationUntranslated RNAVariantVariationVisualizationWorkdevelopmentalepigeneticallyfruit flygenetic regulatory elementgenome scalegenome-widegenomewidehuman diseaseimagingimaging approachimaging based approachin vivoinnovateinnovationinnovativelive cell imagelive cell imaginglive cellular imagelive cellular imagingliving systemnoncodingnovelprogramsrecruitsocial rolethree dimensional
Description preview
PROJECT SUMMARY
In multicellular organisms, development and homeostasis require exquisitely precise, dynamic, and coordinated
deployment of complex regulatory programs. As many genes are under the control of vast regulatory regions –
with some enhancers located over a million base pairs away from target genes – we and others have explored
to what…
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